Jiang Xukai 山东大学主页平台管理系统--Home

Jiang Xukai Associate Professor

蒋绪恺，副研究员/博士生导师，泰山学者青年专家、山东省海外优青；中国药学会智能药物专业委员会青年委员、中国药理学会海洋药物药理专业委员会青年委员、山东省生物化学与分子生物学学会理事。主要从事细胞膜系统的结构-动态-功能研究、细胞膜靶向药物设计与作用机制研究，构建了革兰氏阴性细菌和人体肠道、肾脏、肺泡、皮肤、血脑屏障等结构数字孪生模型，用于抗菌药物、抗肿瘤药物、神经系统药物等的设计与研发。以第一/通讯（含共同）在Nature Communications、Advanced Scien... More+

Paper Publications

Home >> Scientific Resear... >> Paper Publication...

[1] 许立美. Interaction of polyethylene nanoplastics with the plasma, endoplasmic reticulum, Golgi apparatus,.... Ecotoxicology and Environmental Safety, 118680, 2025.
[2] 崔錾. In Silico-Guided Discovery of Polysaccharide Derivatives as Adjuvants in Nanoparticle Vaccines fo.... ACS nano, 2025.
[3] 马振宇. Membrane lipid homeostasis dually regulates conformational transition of phosphoethanolamine tran.... NATURE COMMUNICATIONS, 15, 2024.
[4] 刘卓. Enhanced Sampling Molecular Dynamics Simulations Reveal Transport Mechanism of Glycoconjugate Dru.... INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2024.
[5] . Engineering the substrate preference of glucose oxidase for the enzymatic oxidation of xylose. GREEN CHEMISTRY, 26, 4851, 2024.
[6] 朱景一. Molecular Dynamics Simulations Reveal Octanoylated Hyaluronic Acid Enhances Liposome Stability, S.... ACS Omega, 2024.
[7] 赵沙. Engineering the Relatively Conserved Residues in Active Site Architecture of Thermophilic Chitina.... Biomacromolecules, 25, 2023.
[8] 蒋绪恺. Structure-Interaction Relationship of Polymyxins with Lung Surfactant. Journal of Medicianal Chemistry, 66, 16109-16119, 2023.
[9] 马振宇. Molecular dynamics simulations identify the topological weak spots of a protease CN2S8A. 《JOURNAL OF MOLECULAR GRAPHICS & MODELLING》, 124, 2023.
[10] 吴秀芸. Dynamics of loops surrounding the active site architecture in GH5_2 subfamily TfCel5A for cellulo.... BIOTECHNOLOGY FOR BIOFUELS AND BIOPRODUCTS, 2023.
[11] Zhong Li. Molecular insights into the catalytic promiscuity of a bacterial diterpene synthase. NATURE COMMUNICATIONS, 14, 2023.
[12] 许立美. Gasdermin E regulates the stability and activation of EGFR in human non-small cell lung cancer ce.... CELL COMMUNICATION AND SIGNALING , 2023.
[13] 蒋绪恺. 分子模拟在多粘菌素药理机制研究中的应用. Progress in Biochemistry and Biophysics, 50, 1-8, 2023.
[14] 曹雪婷. Molecular Dynamics Simulations Reveal the Conformational Transition of GH33 Sialidases. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24, 2023.
[15] 窦智欣. Data-driven strategies for the computational design of enzyme thermal stability: trends, perspect.... Acta Biochimica et Biophysica Sinica, 55, 343-355, 2023.
[16] . 壳聚糖与细菌细胞膜相互作用的分子动力学研究. PIBB, 50, 1-12, 2023.
[17] 蒋绪恺. An Intelligent Strategy with All-Atom Molecular Dynamics Simulations for the Design of Lipopeptid.... Journal of Medicianal Chemistry, 65, 10001, 2022.
[18] 张鹏. Docking-guided rational engineering of a macrolide glycosyltransferase glycodiversifies epothilon.... COMMUNICATIONS BIOLOGY, 5, 2022.
[19] 刘晓宇. Molecular Insights into the Assembly and Functional Diversification of Typhoid Toxin. MBIO, 13, 2022.
[20] 杨世达. Novel dTDP- l -Rhamnose Synthetic Enzymes (RmlABCD) From Saccharothrix syringae CGMCC 4.1716 for .... Frontiers in Microbiology., 2021.

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Paper Publications

[1] 许立美. Interaction of polyethylene nanoplastics with the plasma, endoplasmic reticulum, Golgi apparatus,.... Ecotoxicology and Environmental Safety, 118680, 2025.

[2] 崔錾. In Silico-Guided Discovery of Polysaccharide Derivatives as Adjuvants in Nanoparticle Vaccines fo.... ACS nano, 2025.

[3] 马振宇. Membrane lipid homeostasis dually regulates conformational transition of phosphoethanolamine tran.... NATURE COMMUNICATIONS, 15, 2024.

[4] 刘卓. Enhanced Sampling Molecular Dynamics Simulations Reveal Transport Mechanism of Glycoconjugate Dru.... INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2024.

[5] . Engineering the substrate preference of glucose oxidase for the enzymatic oxidation of xylose. GREEN CHEMISTRY, 26, 4851, 2024.

[6] 朱景一. Molecular Dynamics Simulations Reveal Octanoylated Hyaluronic Acid Enhances Liposome Stability, S.... ACS Omega, 2024.

[7] 赵沙. Engineering the Relatively Conserved Residues in Active Site Architecture of Thermophilic Chitina.... Biomacromolecules, 25, 2023.

[8] 蒋绪恺. Structure-Interaction Relationship of Polymyxins with Lung Surfactant. Journal of Medicianal Chemistry, 66, 16109-16119, 2023.

[9] 马振宇. Molecular dynamics simulations identify the topological weak spots of a protease CN2S8A. 《JOURNAL OF MOLECULAR GRAPHICS & MODELLING》, 124, 2023.

[10] 吴秀芸. Dynamics of loops surrounding the active site architecture in GH5_2 subfamily TfCel5A for cellulo.... BIOTECHNOLOGY FOR BIOFUELS AND BIOPRODUCTS, 2023.

[11] Zhong Li. Molecular insights into the catalytic promiscuity of a bacterial diterpene synthase. NATURE COMMUNICATIONS, 14, 2023.

[12] 许立美. Gasdermin E regulates the stability and activation of EGFR in human non-small cell lung cancer ce.... CELL COMMUNICATION AND SIGNALING , 2023.

[13] 蒋绪恺. 分子模拟在多粘菌素药理机制研究中的应用. Progress in Biochemistry and Biophysics, 50, 1-8, 2023.

[14] 曹雪婷. Molecular Dynamics Simulations Reveal the Conformational Transition of GH33 Sialidases. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24, 2023.

[15] 窦智欣. Data-driven strategies for the computational design of enzyme thermal stability: trends, perspect.... Acta Biochimica et Biophysica Sinica, 55, 343-355, 2023.

[16] . 壳聚糖与细菌细胞膜相互作用的分子动力学研究. PIBB, 50, 1-12, 2023.

[17] 蒋绪恺. An Intelligent Strategy with All-Atom Molecular Dynamics Simulations for the Design of Lipopeptid.... Journal of Medicianal Chemistry, 65, 10001, 2022.

[18] 张鹏. Docking-guided rational engineering of a macrolide glycosyltransferase glycodiversifies epothilon.... COMMUNICATIONS BIOLOGY, 5, 2022.

[19] 刘晓宇. Molecular Insights into the Assembly and Functional Diversification of Typhoid Toxin. MBIO, 13, 2022.

[20] 杨世达. Novel dTDP- l -Rhamnose Synthetic Enzymes (RmlABCD) From Saccharothrix syringae CGMCC 4.1716 for .... Frontiers in Microbiology., 2021.