Zhao Shigang
Professor
Associate professor, M.D.,Ph.D., young scholar of Shandong University (future plan). Under the guidance of China's renowned reproductive medicine expert, Academician Zi-Jiang Chen, mainly engaged in the precise subtyping and diagnosis of major reproductive endocrine metabolic diseases in women, committed to exploring the interaction of gender-metabolism-immunity-aging in female reproduction. Has published/participated in over 50 SCI papers, ap... More+
Paper Publications
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[1] Data-driven subtypes of polycystic ovary syndrome and their association with clinical outcomes. Nature Medicine, 2025.
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[2] Multi-ancestry genome-wide association analyses of polycystic ovary syndrome. Nature Genetics, 2025.
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[3] Caloric restriction prevents inheritance of polycystic ovary syndrome through oocyte-mediated DNA methylation reprogramming. Cell metabolism, 2025.
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[4] Population-level analyses identify host and environmental variables influencing the vaginal microbiome. Signal Transduction and Targeted Therapy, 2025.
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[5] Maternal adiposity and perinatal and offspring outcomes: an umbrella review. Nature Human Behaviour, 2024.
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[6] THADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic β-cell function and preserving β-cell mass. Nature Communications, 14, 2023.
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[7] Three-dimensional genome structures of single mammalian sperm. Nature Communications, 2025.
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[8] Bariatric Surgery Impact on Women with Polycystic Ovary Syndrome: A Prospective Cohort Study. Research, 2025.
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[9] Unveiling lipoprotein subfractions signature in high-FNPO PCOS: implications for PCOM diagnosis and risk assessment using advanced machine learning models. BMC Medicine, 2025.
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[10] DENND1A desensitizes granulosa cells to FSH by arresting intracellular FSHR transportation. Science China Life Science, 2024.
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[11] Peripheral blood RNA modifications as a novel diagnostic signature for polycystic ovary syndrome.. Science China Life Science, 2025.
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[12] ZP2: the precision regulator of egg coat architecture during fertilization.. Science China Life Science, 2024.
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[13] . Cellular atlases of ovarian microenvironment alterations by diet and genetically-induced obesity. Science China-life sciences, 2024.
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[14] snRNA-seq of human ovaries reveals heat shock proteins are associated with obesity related cancer risk. Journal of Translational Medicine, 2024.
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[15] CHK1 controls zygote pronuclear envelope breakdown by regulating F-actin through interacting with MICAL3. EMBO Reports, 2024.
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[16] Deciphering the DNA methylome in women with PCOS diagnosed using the new international evidence-based guidelines. Human Reproduction, 2023.
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[17] Novel WEE2 gene variants identified in patients with fertilization failure and female infertility. Fertility and Sterility, 111, 519, 2019.
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[18] The impact of sleep on in vitro fertilization embryo transfer outcomes: a prospective study. Fertility and Sterility, 119, 47, 2023.
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[19] Melatonin promotes human oocyte maturation and early embryo development by enhancing clathrin-mediated endocytosis. Journal of Pineal Research, 2019.
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[20] No Association of Polycystic Ovary Syndrome with Pancreatic Cancer: A Mendelian Randomization Study. Phenomics, 2024.