研究方向:固有免疫激活及调控机制研究
聚焦固有免疫激活及调控的分子机制,以病毒感染及肿瘤为模型,揭示细胞内环境、代谢及组织微环境等在固有免疫活化中的作用及机制,阐明病毒及肿瘤的免疫逃逸机制,为相关疾病治疗提供理论依据。
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- . Lipid droplets restrict phagosome formation in antifungal immunity. CELLULAR & MOLECULAR IMMUNOLOGY, 2025.
- 王子奇. The deubiquitinase cofactor UAF1 interacts with USP1 and plays an essential role in spermiogenesis. eScience, 2024.
- . S-nitrosothiol homeostasis maintained by ADH5 facilitates STING-dependent host defense against pathogens. NATURE COMMUNICATIONS, 2024.
- 吕琳. Selenoprotein K enhances STING oligomerization to facilitate antiviral response. PLOS Pathogens, 19, 2024.
- . Myristic acid as a checkpoint to regulate STING-dependent autophagy and interferon responses by promoting N-myristoylation. NATURE COMMUNICATIONS, 2024.
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