Qingzeng Zhu
Professor Supervisor of Doctorate Candidates Supervisor of Master's Candidates
Name (Simplified Chinese):Qingzeng Zhu
Name (English):Qingzeng Zhu
Name (Pinyin):Zhu Qingzeng
E-Mail:qzzhu@sdu.edu.cn
Date of Employment:1997-07-01
School/Department:Shandong University
Administrative Position:Professor
Education Level:Postgraduate (Postdoctoral)
Business Address:Shandong University (Main campus), Jinan
Gender:Male
Contact Information:qzzhu@sdu.edu.cn
Degree:Doctor
Status:Employed
Alma Mater:Shandong University
Whether on the job:1
Discipline:Materialogy
Chemistry and Physics of Polymers
Academic Honor:
Honors and Titles:
2023-12-01 泰山产业领军人才
2020-05-20 Key supporting regions of Shandong Province talents project (2020)
2017 Weifang Yuandu industry leading talent project (2017)
2015 Taishan industry leading talent project (2015)
Hits:
Journal:Chinese Science Bulletin
Key Words:polysilsesquioxane, photoresponsive, bridged, nanocarriers, controlled release system, DOX
Abstract:本文设计并合成了氨基甲酸N, N双[3 (三甲氧基硅基)丙基] (2硝基苯基)甲酯（BS）光响应性桥联硅烷单体，采用1H NMR、13C NMR、29Si NMR和质谱对合成的桥联硅烷进行了表征，硅烷的邻硝基苄基桥联结构单元具有光响应性能，在254 nm光照射下会发生光致断裂。BS桥联硅烷经过溶胶凝胶过程制备了具有光响应性能的聚倍半硅氧烷纳米粒子（BPS），平均直径为127 nm，粒径分布窄（PDI=0.167）。在254 nm光照射下BPS有机桥联结构发生光致断裂反应，表面电荷性质发生由负（–28.20 mV）到正（+22.86 mV）的翻转，BPS纳米粒子通过静电相互作用能够高效装载阿霉素药物，并具有光控药物释放行为。体外释放实验表明，在254 nm光照射下药物的释放率与光照强度和光照时间正相关，可对药物实现定时、定位和定量地精确控制释放，最高药物释放率为82.9 %，该研究为目标分子的控制释放提供了一种新的聚倍半硅氧烷可控释放体系，具有重要应用价值。
Indexed by:Journal paper
Discipline:Natural Science
Translation or Not:no
Date of Publication:2021-01-01
