Xuexiang Du
Professor
XueXiang Du, Ph.D., Professor, and Ph.D. Supervisor Deputy Director of Shandong Provincial Key Laboratory of Malignant Tumor Diagnosis and Treatment, Recipient of the Shandong Overseas Outstanding Youth Fund, Taishan Scholar Young Expert, Leading Talent of Haiyou Famous Innovators Team in Jinan, First-Level Qilu Young Scholar. Education and Professional Experience: 2009-2015: Pursued integrated Master's and Ph.D. studies at the Institute of Bi... More+
Research Focus
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Research Focus
[1] 重新评估并阐明CTLA-4抗体抗肿瘤的主要作用机制，为提高肿瘤免疫治疗有效性提供理论基础，助力研发更有效的CTLA-4抗体。
[2] 建立能够模拟临床CTLA-4抗体治疗导致的免疫相关副作用的最佳动物模型，提出抗肿瘤效果与免疫相关副作用非关联存在的新理论，以此为基础研制的第二代CTLA-4抗体已经在美国和中国开展癌症病人临床试验。
[3] 首次发现抗体的pH敏感性与副作用相关，揭示了CTLA-4抗体产生免疫相关副作用新机制，同时探索出多种减少副作用新方案。
[4] 发现IL-21和HyperIL-15通过改变免疫抑制性微环境打破肿瘤免疫耐受，促进肿瘤抗原特异T细胞的功能治疗肿瘤，进一步提高治疗有效性。