2025：
29. Huimei Wang, Xing Zhao, Denghui Li, Liang Meng, Shanshan Liu, Youming Zhang, and Liujie Huo*, Marine Metagenome Mining Reveals Lanthipeptides Colwesin A−C, Exhibiting Novel Ring Topology and Anti-inflammatory Activity, ACS Synthetic Biology 2025 Apr 18;14(4):1014-1020. DOI: 10.1021/acssynbio.5c00057
28. Yuan Gu#, Zong-Jie Wang#, Huimei Wang#, Anqi Su, Quan Dai, Youming Zhang, Liujie Huo*, Fu Yan*, Biosynthetic Investigations of Ulbactins Unveil Two Novel Thiazolinyl Imine Reductases Crucial for the Generation of Siderophore Activity, Journal of Agricultural and Food Chemistry 2025 73 (14), 8352-8366, DOI: 10.1021/acs.jafc.5c02142
2024：
27. Ruiying Feng, Quan Dai, Meina Ma, Shuang Zhao, Zongjie Wang, Huimei Wang, Youming Zhang, Liujie Huo*, and Fu Yan*, Discovery of Ureido-Containing Alteropeptilides and Intramolecular Cyclized Alteramides in Pseudoalteromonas flavipulchra S16 by Promoter Engineering of Cryptic Biosynthetic Gene Clusters, Journal of Natural Products 2024 87 (12), 2801-2809, DOI: 10.1021/acs.jnatprod.4c00965
2023：
26. Huimei Wang, Yu Han, Xiaotong Wang, Yujia Jia, Youming Zhang, Rolf Müller, and Liujie Huo*, Genome Mining of Myxopeptins Reveals a Class of Lanthipeptide-Derived Linear Dehydroamino Acid-Containing Peptides from Myxococcus sp. MCy9171, ACS Chemical Biology 2023 Oct 20;18(10):2163-2169. DOI: 10.1021/acschembio.3c00265
25. Xiaotong Wang#, Xiaoyu Chen#, Zong-jie Wang, Mengwei Zhuang, Lin Zhong, Chengzhang Fu, Ronald Garcia, Rolf Müller, Youming Zhang, Jie Yan,* Dalei Wu*, and Liujie Huo*, Discovery and Characterization of a Myxobacterial Lanthipeptide with Unique Biosynthetic Features and Anti-inflammatory Activity, Journal of the American Chemical Society 2023 Aug 2;145(30):16924-16937. DOI: 10.1021/jacs.3c06014.
24. Xiaotong Wang, Zongjie Wang, Zhiqi Dong, Yihai Yan, Youming Zhang, and Liujie Huo*, Deciphering the Biosynthesis of Novel Class I Lanthipeptides from Marine Pseudoalteromonas Reveals a Dehydratase PsfB with Dethiolation Activity, ACS Chemical Biology 2023 18 (5), 1218-1227. DOI: 10.1021/acschembio.3c00135.
23. Zhong, G.; Wang, Z-J.; Yan, F.; Zhang, Y.; Huo, L.*, Recent Advances in Discovery, Bioengineering, and Bioactivity-Evaluation of Ribosomally Synthesized and Post-translationally Modified Peptides, ACS Bio & Med Chem Au 2023 3 (1), 1-31. DOI: 10.1021/acsbiomedchemau.2c00062.
ACS Editors’ Choices:
22. Wang, H.; Pang, A.; Li, B.; Huo, L.; Wu, F.; Lin, F.*, Intracellular Sugar Transporters Facilitate Cellulase Synthesis in Trichoderma reesei Using Lactose, Biomolecules 2023, 13(2), 295. DOI: 10.3390/biom13020295.
2022：
21. Fan, G.; Han, Y.; Zhang, Y.;Huo, L.*, Structure and activity relationships of the two-component lantibiotic bicereucin. ACS Infectious Diseases 2022 8 (12), 2529-2539. DOI: 10.1021/acsinfecdis.2c00371.
20. Wang, T.#; Wang, X.#; Zhao, H.; Huo, L.*; Fu, C.*, Uncovering a subtype of microviridins via the biosynthesis study of FR901451. ACS Chemical Biology 2022 17 (12), 3489-3498. DOI: 10.1021/acschembio.2c00688.
19. Wang, X.; Song, C.; Qi, Q.; Zhang, Y.*; Li, R.*; Huo, L.*, Biochemical characterization of a polyethylene terephthalate hydrolase and design of high-throughput screening for its directed evolution. Engineering Microbiology 2022, 2 (100020). DOI:doi.org/10.1016/j.engmic.2022.100020
18. Han, Y.; Wang, X.; Zhang, Y.; Huo, L.*, Discovery and Characterization of Marinsedin, a New Class II Lanthipeptide Derived from Marine Bacterium Marinicella sediminis F2T. ACS Chemical Biology 2022, 17(4):785-790. DOI: 10.1021/acschembio.2c00021.
17. Shen, Q.; Zhou, H.; Dai, G.; Zhong, G.; Huo, L.; Li, A.; Liu, Y.; Yang, M.; Ravichandran, V.; Zheng, Z., Tang J.; Jiao N.; Zhang Y.; Bian X.*, Characterization of a Cryptic NRPS Gene Cluster in Bacillus velezensis FZB42 Reveals a Discrete Oxidase Involved in Methimazole Biosynthesis. ACS Catalysis 2022, 3371-3381. DOI: 10.1021/acscatal.1c05131
16. Pang, L.; Niu, W.; Duan, Y.; Huo, L.; Li, A.; Wu, J.; Zhang, Y.; Bian, X.*; Zhong, G.*, In vitro characterization of a nitro-forming oxygenase involved in 3-(trans-2’-aminocyclopropyl) alanine biosynthesis. Engineering Microbiology 2022, 2 (100007). DOI: doi.org/10.1016/j.engmic.2021.100007
2020:
15. Wang, Z. J.; Zhou, H.; Zhong, G.; Huo, L.; Tang, Y. J.; Zhang, Y.*; Bian, X.*, Genome Mining and Biosynthesis of Primary Amine-Acylated Desferrioxamines in a Marine Gliding Bacterium. Organic Letters 2020, 22 (3), 939-943. DOI: 10.1021/acs.orglett.9b04490
14. Huo, L.; Zhao, X.; Acedo, J. Z.; Estrada, P.; Nair, S. K.; van der Donk, W. A.*, Characterization of a Dehydratase and Methyltransferase in the Biosynthesis of Ribosomally Synthesized and Post-translationally Modified Peptides in Lachnospiraceae. ChemBioChem 2020, 21 (1-2), 190-199. DOI: 10.1002/cbic.201900483
2019:
13. Huo, L.; Hug, J. J.; Fu, C.; Bian, X.*; Zhang, Y.*; Müller, R.*, Heterologous expression of bacterial natural product biosynthetic pathways. Natural Product Reports 2019, 36 (10), 1412-1436. DOI: 10.1039/c8np00091c
12. Chen, H.; Bian, Z.; Ravichandran, V.; Li, R.; Sun, Y.; Huo, L.; Fu, J.; Bian, X.; Xia, L.; Tu, Q., et al., Biosynthesis of polyketides by trans-AT polyketide synthases in Burkholderiales. Critical Reviews in Microbiology 2019, 45 (2), 162-181. DOI: 10.1080/1040841X.2018.1514365
11. Bobeica, S. C.#; Dong, S. H.#; Huo, L.; Mazo, N.; McLaughlin, M. I.; Jimenez-Oses, G.; Nair, S. K.*; van der Donk, W. A.*, Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease. eLife 2019, 8. DOI: 10.7554/eLife.42305
2018:
10. Wang, X.; Zhou, H.; Chen, H.; Jing, X.; Zheng, W.; Li, R.; Sun, T.; Liu, J.; Fu, J.; Huo, L., et al., Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species. Proceedings of the National Academy of Sciences of the United States of America 2018, 115 (18), E4255-E4263. DOI: 10.1073/pnas.1720941115
2017:
9. Huo, L.; Ökesli, A.; Zhao, M.; van der Donk, W. A.*, Insights into the Biosynthesis of Duramycin. Applied and Environmental Microbiology 2017, 83 (3). DOI: 10.1128/AEM.02698-16
8. Gemperlein, K.; Hoffmann, M. ; Huo, L.; Pilak, P.; Petzke, L.; Müller, R.; Wenzel, S. C.*, Synthetic biology approaches to establish a heterologous production system for coronatines. Metabolic Engineering 2017, 44, 213-222. DOI: 10.1016/j.ymben.2017.09.009
2016:
7. Mukherjee, S.; Huo, L.; Thibodeaux, G. N.; van der Donk, W. A.*, Synthesis and Bioactivity of Diastereomers of the Virulence Lanthipeptide Cytolysin. Organic Letters 2016, 18 (23), 6188-6191. DOI: 10.1021/acs.orglett.6b03246
6. Mann, G.#; Huo, L.#; Adam, S.; Nardone, B.; Vendome, J.; Westwood, N. J.; Müller, R.; Koehnke, J.*, Structure and Substrate Recognition of the Bottromycin Maturation Enzyme BotP. ChemBioChem 2016, 17 (23), 2286-2292. DOI: 10.1002/cbic.201600406
5. Huo, L.; van der Donk, W. A.*, Discovery and Characterization of Bicereucin, an Unusual D-Amino Acid-Containing Mixed Two-Component Lantibiotic. Journal of the American Chemical Society 2016, 138 (16), 5254-7. DOI: 10.1021/jacs.6b02513
2012:
4. Huo, L.; Rachid, S.; Stadler, M.; Wenzel, S. C.*; Müller, R.*, Synthetic biotechnology to study and engineer ribosomal bottromycin biosynthesis.Chemistry & Biology (Cell Chemical Biology) 2012, 19 (10), 1278-87. DOI: 10.1016/j.chembiol.2012.08.013
3. Barbie, P.; Huo, L.; Müller, R.; Kazmaier, U., Stereoselective synthesis of deuterium-labeled (2S)-cyclohexenyl alanines, biosynthetic intermediates of cinnabaramide.Organic Letters 2012, 14 (23), 6064-7. DOI: 10.1021/ol3029548
2011:
2. Rachid, S.; Huo, L.; Herrmann, J.; Stadler, M.; Köpcke, B.; Bitzer, J.; Müller, R.*, Mining the cinnabaramide biosynthetic pathway to generate novel proteasome inhibitors. ChemBioChem 2011, 12 (6), 922-31. DOI: 10.1002/cbic.201100024
1. Quade, N.#; Huo, L.#; Rachid, S.; Heinz, D. W.*; Müller, R.*, Unusual carbon fixation gives rise to diverse polyketide extender units. Nature Chemical Biology 2011, 8 (1), 117-24. DOI: 10.1038/nchembio.734