Zhenling Peng   

Title:Professor
Supervisor of Doctorate Candidates
Supervisor of Master's Candidates

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Language:English

Biography

I am a bioinformatics researcher dedicated to addressing two fundamental challenges in the field: protein structure prediction and functional annotation, with the goal of advancing their applications in complex biological systems.


Protein structure prediction

  • Co-developed the mTM-align algorithm for multi-template structural alignment and established its widely used online server (adopted by researchers in over 50 countries).

  • Contributed to cutting-edge deep learning-based methods, including MapPred and trRosetta (trRosetta ranked among top performers in recent CASP competitions).

  • Extended the trRosetta framework to RNA structure prediction, creating trRosettaRNA, which outperformed other deep learning methods in CASP15 and RNA-Puzzles experiments.


Protein function prediction

  • Developed pioneering tools (DisoRDPbind, CLIP) for identifying functional motifs in intrinsically disordered proteins (IDPs), demonstrating superior accuracy in predicting biomolecule-binding regions.

  • Designed sequence-based binding site predictors (NucBind, CoABind) and enhanced databases (COACH-D, Q-BioLip) to support protein-ligand interaction studies.


Future Directions

  • Deciphering the dynamic structure and functional mechanisms of IDPs.

  • Advancing computational strategies for protein directed evolution.


Academic Contributions

  • Published 40+ SCI-indexed papers in leading journals including PNAS, Nature Communications, Nature Protocols, Advanced Science, and Nucleic Acids Research (total citations >3,000; one paper cited 800+ times).

  • Principal Investigator of 4 national grants, including the NSFC Excellent Young Scholars Program and sub-projects of China's National Key R&D Program.


Education

  • 2010.9-2014.11  

    University of Alberta, Canada       Software Engineering and Intelligent Systems       Postgraduate (Doctoral)       Doctoral Degree in Philosophy

  • 2005.9-2008.6  

    Xiangtan University       Applied Mathematics       Postgraduate (Master's Degree)       Master

  • 2001.9-2005.6  

    Hengyang Normal University       Applied Mathematics       University student       Bachelor

Professional Experience

  • 2021.04-Now

    Shandong University      Research Center for Mathematics and Interdisciplinary Sciences (Frontiers Science Center for Nonlinear Expectations)      Professor

  • 2015.01-2021.03

    Tianjin University      The Center for Applied Mathematics      Associated professor

  • 2018.09-2019.09

    University of Washington, Seattle, USA      Biochemistry      Visitor

Research Group

Team Name :

Bioinformatics Team

Team Introduction :

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