个人简介
张永强
教授、博士生导师
海外高层次青年人才项目
山东省泰山青年学者、山东大学齐鲁学者
地址：济南市山大南路27号生命北楼507室
Email: yongqzhang@sdu.edu.cn
学习及工作经历
2019.1-至今 山东大学，化学化工学院，教授
2018.1-2018.12 德国波恩大学药学所，博士后
2014.1-2017.12 德国波恩大学凯库勒有机与生物化学研究所，洪堡学者
2012.1-2013.12 美国佐治亚州立大学化学系，博士后
2002.9-2011.12 兰州大学 功能有机分子国家重点实验室，学士、博士
研究领域和兴趣
1. 不对称催化
2. 天然产物及药物合成、药物化学
主讲课程
1. 有机化学 （本科）
2. 高等有机化学 （研究生）
热忱欢迎对有机化学和药物化学感兴趣的本科生、硕士生、博士生参观访问、加盟。
课题组招聘理论计算化学专业博士后、科研助理。
发表论文
23. Li, Longfei; Chen, Wanjiao; Xu, Zhongyun; Jiang, Jie; Zhang, Yong-Qiang*
Enantioselective Synthesis of (R)-Tiagabine via Asymmetric Hydrogen Atom Transfer Protocol
Synthesis. 2023, in press, DOI: 10.1055/a-2039-6180.
祝贺硕士生李龙飞同学利用课题组发展的不对称HAT策略实现了手性治疗癫痫药物噻加宾的合成。
22. Xu, Zhongyun; Shen, Jian; Li, Longfei,; Chen, Wanjiao; Li, Shengxiao; Jiang, Jie; Zhang, Yong-Qiang*
(Salen)Titanium-Catalyzed Asymmetric Hydrogen Atom Transfer for Epoxides Reduction
Angew. Chem. Int. Ed. 2022, 61, e202214111.
祝贺课题组第1位硕士毕业生徐忠芸同学：实现了首例配位诱导的催化不对称氢原子转移反应 The first case of coordination-induced catalytic asymmetric HAT reaction 。
***********************************************
21. Zhang, Y. –Q.; Bohle. F.; Bleith, R.; Schnakenburg, G.; Grimme, S.*; Gansäuer, A.*. Synthesis of 1,3-amino alcohols by hydroxyl-directed aziridination and aziridine hydrosilylation.
Angew. Chem. Int. Ed. 2018, 57, 13528-13532.
20. Zhang, Y. -Q.; Vogelsang, E.; Qu, Z.-W.; Grimme, S.; Gansäuer, A.*. Titanocene-catalyzed radical opening of N-acylated aziridines.
Angew. Chem. Int. Ed. 2017, 56, 12654-12657.
(Highlighted by Synfacts, 2017, 13, 1303.)
19. Zhang, Y. -Q.; Poppel, C.; Panfilova, A.; Bohle, F.; Gansäuer, A.*. SN2 at tertiary carbon centers in epoxides.
Angew. Chem. Int. Ed. 2017, 56, 9851-9854.
18. Zhang, Y. -Q.; Jakoby, V.; Stainer, K.; Schmer, A.; Klare, S.; Bauer, M.; Grimme, S.; Cuerva, J. M.; Gansäuer, A.*. Amide-substituted titanocenes in HAT-catalysis.
Angew. Chem. Int. Ed. 2016, 55, 1523-1526.
(Front cover, hot paper)
17. Zhang, Y. -Q.; Funken, N.; Winterscheid, P.; Gansäuer, A.* Hydroxy-directed, fluoride-catalyzed epoxide Hydrosilylation for the synthesis of 1,4-Diols.
Angew. Chem. Int. Ed. 2015, 54, 6931-6934.
(Highlighted by Org. Chem. Highlights 2016, March 21)
16. Funken, N.#; Zhang, Y. –Q. #; Gansäuer, A.*. Regiodivergent catalysis: A powerful tool for selective catalysis. (#equal contribution)
Chem. Eur. J. 2017, 23, 19-32.
15. Zhang, Y. -Q.; Yuan, Y. –A.; Liu, G. –S.; Xu, H.*. Iron(II)-catalyzed intramolecular asymmetric aminohydroxylation of indoles.
Org. Lett. 2013, 15, 3910-3913.
(Highlighted by Synfacts 2013, 9, 1204.)
14. Zhang, Y. -Q.; Zhu, D. -Y.; Li, B. -S.; Tu, Y. -Q.*; Liu, J. -X.; Lu, Y.; Wang,S. –H.. Palladim-Catalyzed cascade process to construct 1,2,5-trisubstituted pyrroles.
J. Org. Chem. 2012, 77, 4167-4170.
13. Zhang, Y. -Q.; Zhu, D. -Y.; Jiao, Z. -W.; Li, B. -S.; Zhang, F. -M.; Tu, Y. -Q.*; Bi, Z.. Regiodivergent annulations of alkynyl indoles to construct spiro-pseudoindoxyl and tetrahydro-β-carbolines.
Org. Lett. 2011, 13, 3458-3461.
12. Zhang, Y. -Q.; Chen, Z. -H.; Tu, Y. -Q.*; Fan, C. -A.; Zhang, F. -M.; Wang, A. -X.; Yuan, D. -Y.. Gold-catalyzed reaction of enynols by a dimerization-fragmentation process: An expeditious assembly of enyne molecular architecture.
Chem. Commun. 2009, 45, 2706-2708.
11. Zhang, Y. -Q.#; Liu, J. –D.#; Xu, H.*. Copper(II)-catalyzed trifluoromethylation of N-aryl imines. (# equal contribution)
Org. Biomol. Chem. 2013, 11, 6242-6245.
10. Zhu, C.#; Zhang, Y. -Q.#;Yuan, Y.-A.; Xu, H.*. Copper-catalyzed aerobic C-H trifluoromethylation of phenanthrolines. (# equal contribution)
Synlett 2015, 26, 345-349.
9. Liu, G. -S.; Zhang, Y. -Q.; Yuan, Y. -A.; Xu, H.*. Iron (II) catalyzed intramolecular aminohydroxylation of olefins with functionalized hydroxylamines.
J. Am. Chem. Soc. 2013, 135, 3343-3346.
8. Chen, Z.-H.; Zhang, Y. -Q.; Chen, Z.-M.; Tu, Y. -Q.*; Zhang, F. -M.. Total synthesis of (±)-maistemonine and (±)-stemonamide.
Chem. Commun. 2011, 47, 1836-1838.
7. Chen, Z.-H.; Chen, Z.-M.; Zhang, Y. -Q.; Tu, Y. -Q.*; Zhang, F. -M.. Total synthesis of (±)-maistemonine, (±)-stemonamide, and (±)-isomaistemonine.
J. Org. Chem. 2011, 76, 10173-10186.
6. Li, B. -S.; Yang, B. -M.; Wang, S. -H.; Zhang, Y. -Q.; Cao, X. -P.; Tu, Y. -Q.* Copper(I)-catalyzed intramolecular [2 + 2] cycloaddition of 1,6-enyne-derived ketenimine: An efficient construction of strained and bridged 7-substituted-3-heterobicyclo[3.1.1]heptan-6-one.
Chem. Sci. 2012, 3, 1975-1979.
5. Jiao, Z. –W; Zhang, S. -Y.; Tu, Y. -Q.*; Wang, S. -H.; Zhang, F. -M.; Zhang, Y. -Q.; Li, H.; He, C. Organocatalytic Asymmetric Direct C-H Functionalization of Ethers: A highly efficient approach to chiral spiroethers.
Angew. Chem., Int. Ed. 2012, 51, 8811-8815.
4. Zhao, X.; Zhang, E.; Tu, Y. -Q.*; Zhang, Y. -Q.; Yuan, D. -Y.; Cao, K.; Fan, C. -A.; Zhang, F. -M.. Au(I)-catalyzed rearrangement reaction of propargylic aziridine: synthesis of trisubstituted and cycloalkene-fused Pyrroles.
Org. Lett. 2009, 11, 4002-4004.
3. Zhang, X. -M.; Tu, Y. -Q.*; Jiang, Y. -J.; Zhang, Y. -Q.; Fan, C. -A.; Zhang, F. -M.. Tandem reactions of cis-2-acyl-1-alkynyl-1-aryl cyclopropanes tuned by gold(I) and silver(I) catalysts: Efficient synthesis of pyran-fused indene cores and 2,4,6-trisubstituted phenols.
Chem. Commun. 2009, 45, 4726 -4728.
2. Liu, J. -D.; Wang, S. -H.; Zhang, F. -M.; Tu, Y. -Q.*; Zhang, Y. -Q.. Concise total synthesis of (±)-crinine.
Synlett 2009, 18, 3040 -3042.
1. Zhang, F. -M.; Tu, Y. -Q.*; Liu, J. -D.; Fan, X. -H.; Shi, L.; Hu, X. -D.; Wang, S. -H.; Zhang, Y. -Q.. A general approach to crinine-type Amaryllidaceae alkaloids: total syntheses of (±)-haemanthidine, (±)-pretazettine, (±)-tazettine, and (±)-crinamine.
Tetrahedron 2006, 62, 9446-9455.
教育经历
[1] 2002.9-2006.6
兰州大学 | 化学
工作经历
[1] 2014.1-2019.1
波恩大学
[2] 2012.1-2013.12
佐治亚州立大学
[3] 2018.12-至今
山东大学