刘相国
教授
所属院部： 生命科学学院
访问次数：次
基本信息
  • 教师英文名称：
    Liu Xiangguo
  • 教师拼音名称：
    Liu Xiangguo
  • 入职时间：
    2008-10-27
  • 所在单位：
    生命科学学院
  • 职务：
    教授
  • 学历：
    研究生(博士)毕业
  • 办公地点：
    山东大学青岛校区N8
  • 性别：
    男
  • 联系方式：
    liuxiangguocells@163.com
  • 学位：
    博士
  • 在职信息：
    在职
  • 其他任职：
    山东细胞生物学学会理事长
  • 毕业院校：
    中国科学院大学（中国科学院微生物研究所）
  • 博士生导师
  • 硕士生导师
学科：
细胞生物学；
曾获荣誉：

2017-12-30    泉城产业领军人才；
2010    山东省自然科学杰出青年基金；
2009    新世纪优秀人才；
学术荣誉：

2009    教育部“新世纪优秀人才支持计划“入选者；
教师简介

山东大学生命科学学院教授、博导。1990-1994在山东大学获得学士学位，1994-1997在山东大学获得硕士学位，2000年在中科院微生物研究所获得博士学位，2000.9-2002.11年在北京大学医学部基础医学院免疫系从事自身免疫病的博士后研究，2002.11-2008.8年在美国Florida大学和Emory大学从事肿瘤生物学博士后研究。2008年回到山东大学生命学院任教授。研究方向为肿瘤细胞信号转导，长期从事肿瘤细胞死亡、转移及肿瘤免疫调控的分子机制研究。主持多项国家自然科学基金、教育部留学回国基金、教育部博士点基金等国家级和省部级项目。2009年获评教育部新世纪优秀人才、2010年获评山东省自然科学杰出青年基金、2017年获评泉城产业领军人才。现为中国细胞生物学学会常务理事、山东细胞生物学学会理事长、《中国细胞生物学学报》编委。已在Autophagy, JNCI, Cancer Res, JBC，Mol Cancer Ther等专业期刊发表论文56篇，引用6400余次，H-index=33。


教育经历
  • 1997-9 — 2000-7
    中科院微生物所
    微生物学
    理学博士学位
  • 1994-9 — 1997-6
    山东大学
    细胞生物学
    理学硕士学位
  • 1990-9 — 1994-7
    山东大学
    生物学
    理学学士学位
工作经历
  • 2008-10-至今
    山东大学生命科学院
  • 2003-9 — 2008-8
    美国EMORY UNIVERSITY
  • 2002-11 — 2003-8
    美国UNIVERSITY OF FLORIDA
  • 2000-9 — 2002-11
    北京大学医学部免疫系
研究领域

肿瘤细胞生物学：肿瘤细胞死亡、转移及肿瘤免疫的调控机制。

科研成果
论文

1.  穆宁. Inhibition of SIRT1/2 upregulates HSPA5 acetylation and induces pro-survival autophagy via ATF4-DDIT4-mTORC1 axis in human lung cancer cells.  Apoptosis,  2019. 

2.  王莹莹. YIPF2 promotes chemotherapeutic agent-mediated apoptosis via enhancing TNFRSF10B recycling to plasma membrane in non-small cell lung cancer cells.  CELL DEATH & DISEASE ,  11,  2020. 

3.  姚舜. Angio-associated migratory cell protein (AAMP) interacts with cell division cycle 42 (CDC42) and enhances migration and invasion in human non-small cell lung cancer cells.  Cancer letters,  502,  1, 2021. 

4.  姚舜. Angio-associated migratory cell protein interacts with epidermal growth factor receptor and enhances proliferation and drug resistance in human non-small cell lung cancer cells.  Cellular Signalling,  61,  10, 2019. 

5.  刘志勇. CD74 interacts with CD44 and enhances tumorigenesis and metastasis via RHOA-mediated cofilin phosphorylation in human breast cancer cells..  ONCOTARGET,  2016. 

6.  安文涛. Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLAR(L) and inhibit apoptosis in human non-small cell lung cancer cells.  Journal of Experimental & Clinical Cancer Research,  2019. 

7.  李明月. The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLAR(L) in human lung cancer cells.  Journal of Experimental & Clinical Cancer Research,  38,  2019. 

8.  李晓鹏. Hhex inhibits cell migration via regulating RHOA/CDC42-CFL1 axis in human lung cancer cells.  19,  2021. 

9.  公倩倩. A novel mouse line with epididymal initial segment-specific expression of Cre recombinase driven by the endogenous Lcn9 promoter.  Plos One,  16,  2021. 

10.  王莹莹. YIPF2 promotes chemotherapeutic agent-mediated apoptosis via enhancing TNFRSF10B recycling to plasma membrane in non-small cell lung cancer cells.  《Cell Death and Disease》,  2020. 

11.  刘相国. A novel derivative of tetrandrine (H1) induces endoplasmic reticulum stress-mediated apoptosis and prosurvival autophagy in human non-small cell lung cancer cells. .  Tumour Biol,  2016. 

12.  张冯瑜. YdiV regulates Escherichia coli ferric uptake by manipulating the DNA-binding ability of Fur in a SlyD-dependent manner.  Nucleic acids research,  48,  9571, 2020. 

13.  王莹莹. YIPF2 promotes chemotherapeutic agent-mediated apoptosis via enhancing TNFRSF10B recycling to plasma membrane in non-small cell lung cancer cells.  CELL DEATH & DISEASE ,  11,  2020. 

14.  崔换天. Traditional Chinese medicine for treatment of coronavirus disease 2019: a review.  TRADITIONAL MEDICINE RESEARCH,  5,  65, 2020. 

15.  Wang, Qilin. The dual functions of alpha-tubulin acetylation in cellular apoptosis and autophage induced by tanespimycin in lung cancer cells.  20,  2020. 

16.  王宇. The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells.  18,  2020. 

17.  Wang, Qilin. VDAC upregulation and alpha TAT1-mediated alpha-tubulin acetylation contribute to tanespimycin-induced apoptosis in Calu-1 cells.  Oncology reports,  44,  2725, 2020. 

18.  崔换天. Untargeted Metabolomic Analysis of the Effects and Mechanism of Nuciferine Treatment on Rats With Nonalcoholic Fatty Liver Disease.  FRONTIERS IN PHARMACOLOGY,  11,  2020. 

19.  姚舜. Angio-associated migratory cell protein (AAMP) interacts with cell division cycle 42 (CDC42) and enhances migration and invasion in human non-small cell lung cancer cells.  Cancer letters,  502,  1, 2021. 

20.  崔换天. Da-Chai-Hu Decoction Ameliorates High Fat Diet-Induced Nonalcoholic Fatty Liver Disease Through Remodeling the Gut Microbiota and Modulating the Serum Metabolism.  FRONTIERS IN PHARMACOLOGY,  11,  2020. 

21.  王莹莹 , 孙晓阳 , 刘相国 , 苏玲  and 姚舜. Angio-associated migratory cell protein interacts with epidermal growth factor receptor and enhances proliferation and drug resistance in human non-small cell lung cancer cells..  Cellular Signalling,  61,  10, 2019. 

22.  王莹莹 , 刘相国 , 苏玲  and 穆宁. Inhibition of SIRT1/2 upregulates HSPA5 acetylation and induces pro-survival autophagy via ATF4-DDIT4-mTORC1 axis in human lung cancer cells.  Apoptosis,  2019. 

23.  刘相国  and 苏玲. Hedgehog信号通路与肿瘤.  生命的化学,  31,  21, 2011. 

24.  苏玲 , 刘相国  and 张牧天. Methyl jasmonate induces apoptosis and pro-apoptotic autophagy via the ROS pathway in human non-small cell lung cancer..  Am J Cancer Res,  6,  187, 2016. 

25.  孙晓阳 , 苏玲 , 刘相国  and 刘志勇. CD74 interacts with CD44 and enhances tumorigenesis and metastasis via RHOA-mediated cofilin phosphorylation in human breast cancer cells..  ONCOTARGET,  2016. 

26.  高建刚 , 孙晓阳 , 刘相国  and 付小龙. Tuberous sclerosis complex–mediated mTORC1 overactivation promotes age-related hearing loss.  The Journal of Clinical Investigation ,  2018. 

27.  苏玲  and 刘相国. Chaetocin induces endoplasmic reticulum stress response and leads to death receptor 5-dependent apoptosis in human non-small cell lung cancer cells..  Apoptosis,  2015. 

28.  苏玲 , 刘相国  and 李天亮. DDIT3 and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung Cancer Cells..  J Biol Chem.,  290,  11108, 2015. 

29.  王燕飞 , 刘相国  and 徐志刚. Endoplasmic Reticulum Stress in Hearing Loss..  Journalof Otorhinolaryngology, Hearing and Balance Medicine.,  1,  2018. 

30.  苏玲  and 刘相国. Loss of CDH1 Up-regulates Epidermal Growth Factor Receptor via Phosphorylation of YBX1 in Non-small Cell Lung Cancer cells..  FEBS Lett,  2013. 

31.  苏玲  and 刘相国. Down-regulation of cellular FLICE-inhibitory protein (Long Form) contributes to apoptosis induced by Hsp90 inhibition in human lung cancer cells..  Cancer Cell Int.,  2012. 

32.  苏玲 , 刘相国  and 李明月. The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLAR(L) in human lung cancer cells.  Journal of Experimental & Clinical Cancer Research,  38,  2019. 

33.  孙晓阳 , 苏玲 , 刘相国  and 安文涛. Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLAR(L) and inhibit apoptosis in human non-small cell lung cancer cells.  Journal of Experimental & Clinical Cancer Research,  38,  2019. 

34.  刘相国  and 苏玲. PKCδ Regulates Death Receptor 5 Expression Induced by PS-341 through ATF4- ATF3/CHOP axis in Human Lung Cancer Cells..  Mol Cancer Ther.,  2012. 

35.  刘相国. 分子伴侣HSP90在肿瘤发生中的作用机制.  山东医药,  51,  113, 2011. 

36.  刘相国  and 苏玲. Death Receptor 5 and cellular FLICE-inhibitory protein regulate pemetrexed-induced apoptosis in human lung cancer cells..  EUR J CANCER,  47,  2471, 2011. 

37.  刘相国. Hsp90 抑制剂在肿瘤细胞中的靶向位点作用机制.  中国免疫学杂志.,  27,  763, 2011. 

38.  韩书华  and 刘相国. A pH-driven molecular shuttle based on rotaxanebridgedperiodic mesoporous organosilicas with responsive release of guests.  Rsc Adv.,  6,  27922, 2016. 

39.  刘相国  and 苏玲. Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells..  Autophagy,  2013. 

40.  刘相国  and 苏玲. The chalcone 2'-hydroxy-4',5'-dimethoxychalcone activates death receptor 5 pathway and leads to apoptosis in human nonsmall cell lung cancer cells..  IUBMB Life,  2013. 

41.  刘相国  and 曹成波. Synthesis and evaluation of novel isoxazolyl chalcones as potential anticancer agents..  Bioorg Chem.,  2014. 

42.  苏玲  and 刘相国. Usp9x- and Noxa-mediated Mcl-1 downregulation contributes to pemetrexed-induced apoptosis in human non-small-cell lung cancer cells..  《Cell Death and Disease》,  2014. 

43.  苏玲  and 刘相国. Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells..  Journal of Experimental & Clinical Cancer Research,  2014. 

44.  刘相国  and 苏玲. Down-regulation of cellular FLICE-inhibitory protein (Long Form) contributes to apoptosis induced by Hsp90 inhibition in human lung cancer cells..  Cancer Cell Int.,  2012. 

45.  刘相国  and 苏玲. Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging..  MOL CELL BIOCHEM,  2012. 

46.  刘相国. 热激蛋白90抑制剂.  生命的化学,  31,  552, 2011. 

47.  刘相国. Involvement of c-FLIP and survivin downregulation in Flex-Het-induced apoptosis and enhancement of TRAIL-initiated apoptosis in lung cancer cells..  Molecular Cancer Ther.,  7,  3556, 2008. 

48.  刘相国  and 苏玲. Salermide Upregulates Death Receptor 5 Expression through the ATF4-ATF3-CHOP Axis and Leads to Apoptosis in Human Cancer Cells. .  j cell mol med,  0,  1, 2012. 

49.  刘相国. FLICE Inhibitory protein..  Encyclopedia of Cancer,  0,  1131, 2008. 

50.  刘相国. ERK/RSK signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1.  J Biol Chem.,  285,  41310, 2010. 

51.  刘相国  and Diansheng Zhong. The glycolytic inhibitor 2-deoxyglucose activates multiple prosurvival pathways through IGF1R..  J Biol Chem.,  284,  23225, 2009. 

52.  苏玲 , 刘相国  and 李明月. The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLAR(L) in human lung cancer cells.  Journal of Experimental & Clinical Cancer Research,  38,  2019. 

53.  孙晓阳 , 苏玲 , 刘相国  and 安文涛. Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLAR(L) and inhibit apoptosis in human non-small cell lung cancer cells.  Journal of Experimental & Clinical Cancer Research,  38,  2019. 

54.  刘相国  and 苏玲. Chaetocin induces endoplasmic reticulum stress response and leads to death receptor 5-dependent apoptosis in human non-small cell lung cancer cells. .  Apoptosis,  2015. 

55.  刘相国  and 韩书华. A pH-driven molecular shuttle based on rotaxanebridgedperiodic mesoporous organosilicas with responsive release of guests.  Rsc Adv.,  6,  27922, 2016. 

56.  刘相国  and 苏玲. Loss of CDH1 Up-regulates Epidermal Growth Factor Receptor via Phosphorylation of YBX1 in Non-small Cell Lung Cancer cells..  FEBS Lett,  2013. 

57.  刘相国  and 苏玲. Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells..  Journal of Experimental & Clinical Cancer Research,  2014. 

58.  刘相国  and 苏玲. Down-regulation of cellular FLICE-inhibitory protein (Long Form) contributes to apoptosis induced by Hsp90 inhibition in human lung cancer cells..  Cancer Cell Int.,  2012. 

59.  刘相国  and Diansheng Zhong. The glycolytic inhibitor 2-deoxyglucose activates multiple prosurvival pathways through IGF1R..  J Biol Chem.,  284,  23225, 2009. 

60.  刘相国  and 韩书华. A pH-driven molecular shuttle based on rotaxanebridgedperiodic mesoporous organosilicas with responsive release of guests.  Rsc Adv.,  6,  27922, 2016. 

61.  刘相国  and 苏玲. Down-regulation of cellular FLICE-inhibitory protein (Long Form) contributes to apoptosis induced by Hsp90 inhibition in human lung cancer cells..  Cancer Cell Int.,  2012. 

62.  刘相国  and 苏玲. Chaetocin induces endoplasmic reticulum stress response and leads to death receptor 5-dependent apoptosis in human non-small cell lung cancer cells. .  Apoptosis,  2015. 

63.  刘相国  and 苏玲. Loss of CDH1 Up-regulates Epidermal Growth Factor Receptor via Phosphorylation of YBX1 in Non-small Cell Lung Cancer cells..  FEBS Lett,  2013. 

64.  刘相国  and 苏玲. Usp9x- and Noxa-mediated Mcl-1 downregulation contributes to pemetrexed-induced apoptosis in human non-small-cell lung cancer cells..  《Cell Death and Disease》,  2014. 

65.  刘相国  and 苏玲. Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells..  Journal of Experimental & Clinical Cancer Research,  2014. 

66.  刘相国  and Diansheng Zhong. The glycolytic inhibitor 2-deoxyglucose activates multiple prosurvival pathways through IGF1R..  J Biol Chem.,  284,  23225, 2009. 

67.  苏玲  and 刘相国. DDIT3 and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung Cancer Cells..  J Biol Chem.,  290,  11108, 2015. 

68.  曹成波  and 刘相国. Synthesis and evaluation of novel isoxazolyl chalcones as potential anticancer agents..  Bioorg Chem.,  2014. 

69.  苏玲  and 刘相国. Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells..  Autophagy,  2013. 

70.  苏玲  and 刘相国. The chalcone 2'-hydroxy-4',5'-dimethoxychalcone activates death receptor 5 pathway and leads to apoptosis in human nonsmall cell lung cancer cells..  IUBMB Life,  2013. 

71.  苏玲  and 刘相国. PKCδ Regulates Death Receptor 5 Expression Induced by PS-341 through ATF4- ATF3/CHOP axis in Human Lung Cancer Cells..  Mol Cancer Ther.,  2012. 

72.  苏玲  and 刘相国. Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging..  MOL CELL BIOCHEM,  2012. 

73.  刘相国. 热激蛋白90抑制剂.  生命的化学,  31,  552, 2011. 

74.  刘相国. 分子伴侣HSP90在肿瘤发生中的作用机制.  山东医药,  51,  113, 2011. 

75.  苏玲  and 刘相国. Salermide Upregulates Death Receptor 5 Expression through the ATF4-ATF3-CHOP Axis and Leads to Apoptosis in Human Cancer Cells. .  j cell mol med,  0,  1, 2012. 

76.  刘相国. Involvement of c-FLIP and survivin downregulation in Flex-Het-induced apoptosis and enhancement of TRAIL-initiated apoptosis in lung cancer cells..  Molecular Cancer Ther.,  7,  3556, 2008. 

77.  刘相国. Hsp90 抑制剂在肿瘤细胞中的靶向位点作用机制.  中国免疫学杂志.,  27,  763, 2011. 

78.  刘相国. FLICE Inhibitory protein..  Encyclopedia of Cancer,  0,  1131, 2008. 

79.  刘相国. ERK/RSK signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1.  J Biol Chem.,  285,  41310, 2010. 

80.  苏玲  and 刘相国. Death Receptor 5 and cellular FLICE-inhibitory protein regulate pemetrexed-induced apoptosis in human lung cancer cells..  EUR J CANCER,  47,  2471, 2011. 

专利

1. 一种基于TRAIL受体信号通路的抗肿瘤药物筛选系统

团队成员
团队名称：
 动物细胞与发育生物学
团队介绍：
 动物细胞与发育生物学团队继承了动物学科传统优势，研究力量雄厚，既有科研经历丰富不忘初心的资深教授，也有初出茅庐朝气蓬勃的年轻学者和研究生群体。目前研究团队包括博导6人，青年教师3人，博士后3人，博士研究生15人，硕士研究生29人。团队的研究方向为利用细胞、人类病理组织与小鼠模型探讨精卵发生与配子源性不孕不育的机制以及肿瘤、心脑血管、代谢等疾病的细胞生物学基础，重点探讨两性配子发育成熟的遗传与表观遗传调控以及疾病发生发展及治疗中细胞死亡、细胞自噬、细胞分化及表观遗传调控机制在其中的作用。近年来在包括Autophagy、JBC、Advanced Science、Cell Stem Cell、PNAS、Molecular Cell等高影响力的期刊发表论文多篇。

刘相国，山东大学生命科学学院教授，博士生导师，山东省动物细胞与发育生物学重点实验室主任，教育部新世纪优秀人才、山东省杰出青年基金获得者，山东细胞生物学学会理事长。研究方向为肿瘤细胞生物学，主要从事肿瘤细胞死亡、肿瘤转移及肿瘤免疫的分子机制和抗肿瘤药物筛选的研究。已在Autophagy、Cancer Research、JNCI、JBC等高水平专业期刊发表论文56篇。联系方式：电话：0532-58630878；邮箱：xgliu@sdu.edu.cn 。
团队成员：
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