教师简介

袁中尚，男，生物统计学专业教授，博士生导师，概率论与数理统计专业博士毕业，齐鲁青年学者，国际生物统计学会中国分会(IBS-China)副秘书长，中国卫生健康医疗大数据学会统计理论与方法专业委员会委员，中国数学会医学数学专委会委员，中国工业统计协会生物统计分会常务理事，山东预防医学会慢性非传染性疾病预防与控制分会第一届委员会委员。2009年5月-2009年6月参加了新加坡国立大学(NUS)基因组暑期班，2009年10月-2010年10月以国家公派联合培养博士生身份访问美国北卡大学教堂山分校(UNC-CH)生物统计系，2011年7月-2013年7月在山东大学公共卫生学院生物统计学系完成了师资博士后研究，2014年7月-2020年7月，在山东省内分泌代谢研究所从事博士后研究，2017年10月-2019年12月，美国密歇根大学生物统计学系访问学者，主要研究方向为跨组学数据整合与系统流行病学统计理论方法，先后主持和承担了国家自然科学基金面上项目3项、山东省自然科学基金重大基础研究1项、国家自然科学基金青年项目、国家重点研发计划子课题、国家科技支撑计划子课题、中国博士后科学基金面上项目、山东省博士后创新专项等，以第一作者或通讯作者在国内外发表SCI论文31篇，参编专著1部。

主要代表性成果：

1.       Zhongshang Yuan; Huanhuan Zhu; Ping Zeng; Sheng Yang; Shiquan Sun; Can Yang; Jin Liu; Xiang Zhou ; Testing and controlling for horizontal pleiotropy with probabilistic Mendelian randomization in transcriptome-wide association studies, Nature Communications, 2020, 11(1): 3861

2.       Zhongshang Yuan; Lu Liu; Ping Guo; Ran Yan; Fuzhong Xue; Xiang Zhou; Likelihood-based Mendelian randomization analysis with automated instrument selection and horizontal pleiotropic modeling, Science Advances, 2022, 8(9)

3.       Lu Liu; Ping Zeng; Fuzhong Xue; Zhongshang Yuan*; Xiang Zhou*; Multi-trait transcriptome-wide association studies with probabilistic Mendelian randomization, The American Journal of Human Genetics, 2021, 108(2): 240-256

4.       Weiming Gong+; Ping Guo+; Yuanming Li; Lu Liu; Ran Yan; Shuai Liu; Shukang Wang; Fuzhong Xue; Xiang Zhou; Zhongshang Yuan*; Role of the Gut-Brain Axis in the Shared Genetic Etiology Between Gastrointestinal Tract Diseases and Psychiatric Disorders: A Genome-Wide Pleiotropic Analysis, JAMA Psychiatry, 2023, Feb 8.

5.     Ping Guo+; Weiming Gong+; Yuanming Li; Lu Liu; Ran Yan; Yanjun Wang; Yanan Zhang; Zhongshang Yuan*; Pinpointing novel risk loci for Lewy body dementia and the shared genetic etiology with Alzheimer’s disease and Parkinson’s disease: a large-scale multi-trait association analysis, BMC Medicine, 2022, 20:214

6.       Yanan Zhang; Meng Zhao; Ping Guo; Yanjun Wang; Lu Liu; Jinghua Zhao; Ling Gao; Zhongshang Yuan*; Fuzhong Xue*; Jiajun Zhao*; Mendelian randomisation highlights hypothyroidism as a causal determinant of idiopathic pulmonary fibrosis, EBioMedicine, 2021, 73: 2352-3964



教育经历
  • 2007-9 — 2011-6
    武汉大学
    概率论与数理统计
    理学博士学位
  • 2005-9 — 2007-6
    武汉大学
    概率论与数理统计
    理学硕士学位
  • 2001-9 — 2005-7
    曲阜师范大学
    数学与应用数学
    理学学士学位
工作经历
  • 2020-09 — 至今
     山东大学公共卫生学院 
    教授
  • 2017-10 — 2020-12
     美国密歇根大学生物统计学系/统计遗传中心 
    访问学者
  • 2016-09 — 2020-09
     山东大学公共卫生学院 
    副教授
  • 2014-10 — 2020-07
     山东省临床医学院内分泌代谢研究所 
    博士后
  • 2012-01 — 2016-09
     山东大学公共卫生学院 
    讲师
  • 2011-07 — 2013-07
     山东大学公共卫生学院 
    师资博士后
学术兼职
  • 山东预防医学会慢性非传染性疾病预防与控制分会第一届委员会委员
  • 中国工业统计协会生物统计分会常务理事
  • 中国数学会医学数学专委会委员
  • 中国卫生信息与健康医疗大数据学会统计理论与方法专业委员会委员
  • 国际生物统计学会中国分会(IBS-China)副秘书长
研究概况


组学数据整合分析与观察性研究因果推断的统计理论方法

论文成果

(1) 韩佳沂.CoNet: Efficient Network Regression for Survival Analysis in Transcriptome-Wide Association Studies-With Applications to Studies of Breast Cancer.GENES.2023,14 (3)

(2) Protein-centric omics integration analysis identifies candidate plasma proteins for multiple autoimmune diseases.《HUMAN GENETICS》.2023 (12)

(3) 李明卓.血脂正常人群HDL-C纵向变化与冠心病的关联性分析:一项回顾性队列研究.山东大学学报医学版.2019,57 (8):110-116

(4) 林伟强.中老年人血压变化轨迹与冠心病发病的关系.山东大学学报医学版.2019,0 (4):106-112

(5) 姜文丽.“党建+”视角下的高校教师样板党支部培育和实践探索.南北桥.2023 (2023年3月上):88

(6) 王金涛.A Multi-Center Competing Risks Model and Its Absolute Risk Calculation Approach.International Journal of Environmental Research and Public Health.2019,16 (18)

(7) Gong, Weiming.Role of the Gut-Brain Axis in the Shared Genetic Etiology Between Gastrointestinal Tract Diseases and Psychiatric Disorders A Genome-Wide Pleiotropic Analysis.JAMA PSYCHIATRY.2023,80 (4):360-370

(8) Li, Mingzhuo.Multi-trajectories of systolic and diastolic hypertension and coronary heart disease in middle-aged and older adults.Frontiers in Public Health.2022,10

(9) 刘玉美.医学类专业学生统计学态度现状调查及相关影响因素分析.山东大学学报医学版.2020 (11):109-114

(10) 刘静.“以学生为中心”理念指导下的《医学统计学》教学综合改革与探索.山东大学学报医学版.2021,59.0 (7.0):119-124

(11) Sensitivity analysis for mistakenly adjusting for mediators in estimating total effect in observational studies.BMJ Open.2018 (7(11):e015640)

(12) Impact of nonrandom selection mechanisms on the causal effect estimation for two-sample Mendelian randomization method.Plos Genetics.2022 (3)

(13) The alarming problems of confounding equivalence using logistic regression models in the perspective of causal diagrams.BMC MEDICAL RESEARCH METHODOLOGY.2017 (177)

(14) 于媛媛.Impact of nonrandom selection mechanisms on the causal effect estimation for two-sample Mendelian randomization methods.Plos Genetics.2022,18 (3):e1010107

(15) Integrative Analysis of Transcriptome-Wide Association Study and Gene-Based Association Analysis Identifies In Silico Candidate Genes Associated with Juvenile Idiopathic Arthritis.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES .2022 (21)

(16) 刘丽媛.Using machine learning to identify gene interaction networks associated with breast cancer.BMC cancer.2022 (1)

(17) 袁中尚.Likelihood-based Mendelian randomization analysis with automated instrument selection and horizontal pleiotropic modeling.科学前沿.2022,8 (9)

(18) 袁中尚.Mendelian randomisation highlights hypothyroidism as a causal determinant of idiopathic pulmonary fibrosis.EBioMedicine.2021 (73)

(19) 袁中尚.Mendelian randomization highlights the causal role of normal thyroid function on blood lipid profiles.Endocrinology.2021 (5)

(20) 袁中尚.Joint Analysis of Genetic Correlation, Mendelian Randomization and Colocalization Highlights the Bi-Directional Causal Association Between Hypothyroidism and Primary Biliary Cirrhosis.Frontiers in Genetics.2021 (12)

(21) Zhongshang Yuan.Testing and controlling for horizontal pleiotropy with the probabilistic Mendelian randomization in transcriptome-wide association studies.Nature communications.2020,11 (3864)

(22) Lu Liu.Multi-trait transcriptome-wide association studies with probabilistic Mendelian randomization.The American Journal of Human Genetics.2021,108 :240-256

(23) Yanjun Wang,Ping Guo.Mendelian randomization highlights the causal role of normal thyroid function on blood lipid profiles.Endocrinology.2021,May 1

(24) Weiming Gong,Ping Guo.Integrative Analysis of Transcriptome-Wide Association Study and mRNA Expression Profiles Identifies Candidate Genes Associated with Idiopathic Pulmonary Fibrosis.Frontiers in Genetics.2020,11 (604324)

(25) Yuchen Zhu,Jiadong Ji.MCC-SP: a powerful integration method for identification of causal pathways from genetic variants to complex disease.BMC Genetics.2020,21 (1)

(26) Lishun Xiao,Zhongshang Yuan.Multiple-Tissue Integrative Transcriptome-Wide Association Studies Discovered New Genes Associated With Amyotrophic Lateral Sclerosis.Frontiers in Genetics.2020,11 (587243)

(27) Weiqiang Lin,Jiadong Ji.PMINR: Pointwise Mutual Information-Based Network Regression - With Application to Studies of Lung Cancer and Alzheimer's Disease.Frontiers in Genetics.2020,11 (556259)

(28) Zhongshang Yuan,Xinghao Yu.Relationship between birth weight and chronic kidney disease: evidence from systematics review and two-sample Mendelian randomization analysis.Human Molecular Genetics.2020,29 (13)

(29) Lu Liu,Ping Zeng.Leveraging methylation to identify the potential causal genes associated with survival in lung adenocarcinoma and lung squamous cell carcinoma.Oncology Letters.2020,20 :193-200

(30) Zhongshang Yuan.A novel chi-square statistic for detecting group differences between pathways in systems epidemiology.Statistics in Medicine.2016,35 (29):5512-5524

(31) Zhongshang Yuan.Trajectories of Long-Term Normal Fasting Plasma Glucose and Risk of Coronary Heart Disease: A Prospective Cohort Study.Journal of the American Heart Association.2018,7 (4)

(32) Zhongshang Yuan,Jiadong Ji.A powerful weighted statistic for detecting group differences of directed biological networks.SCIENTIFIC REPORTS.2016,6

(33) Yufeng Chu,Zhongshang Yuan.Red blood cell distribution width as a risk factor for inhospital mortality in obstetric patients admitted to an intensive care unit: a single centre retrospective cohort study..BMJ Open.2017,Jun 21 (7)

(34) Zhongshang Yuan,Meng Zhao,Bingchang Zhang.Thyroid function modifies the association between ratio of triglyceride to high-density lipoprotein cholesterol and renal function: a multicenter cross-sectional study.SCIENTIFIC REPORTS.2015,5

(35) Zhongshang Yuan,Qingsong Gao.Detection for gene-gene co-association via kernel canonical correlation analysis.BMC Genetics.2012,13 (1):83

(36) Zhongshang Yuan.From interaction to co-association --a Fisher r-to-z transformation-based simple statistic for real world genome-wide association study.PLOS ONE.2013,8 (7)

(37) Zhongshang Yuan.Comparing partial least square approaches in gene-or region-based association study for multiple quantitative phenotypes.Human Biology.2014,86 (1):51-58

(38) Jiadong Ji,Zhongshang Yuan.A powerful score-based statistical test for group difference in weighted biological networks.BMC Bioinformatics.2016,17 (1):86

(39) Xiaoshuai Zhang,Zhongshang Yuan.Network or regression-based methods for disease discrimination: a comparison study.BMC MEDICAL RESEARCH METHODOLOGY.2016

(40) Jing Xu,Zhongshang Yuan.A powerful score-based test statistic for detecting gene-gene co-association.BMC Genetics.2016,17

(41) Lin Zhu,Zhongshang Yuan.The Impact of Ambient Temperature on Childhood HFMD Incidence in Inland and Coastal Area: A Two-City Study in Shandong Province, China.International Journal of Environmental Research and Public Health.2015,12 (8):8691-704

(42) Nannan Gao,Zhongshang Yuan.Prevalence of CHD-related metabolic comorbidity of diabetes mellitus in Northern Chinese adults: the REACTION study.JOURNAL OF DIABETES AND ITS COMPLICATIONS.2016,30 (2):199-205

(43) Zhongshang Yuan.Bayesian Multiple Quantitative Trait Loci Mapping for Recombinant Inbred Intercrosses.Genetics.2011,188 (1):189-U309

(44) 杨青龙.带有辅助信息的多元失效时间数据的估计标准部分似然方法.中国科学. 数学.2012,42 (6):563-577

专利

1. 基于仿造变量的脑网络差异识别系统、设备及存储介质

2. 一种基于孟德尔随机化的多性状全转录组关联分析方法、系统及其应用

科研项目

1. 高校科研人员心理健康早期风险评估方法及干预策略, 2022/11/30-2025/10/31

2. 多重内源相关性校正的全转录组区域化关联分析联合模型构建及统计方法研究, 2023/08/24-2027/12/31

3. 两样本孟德尔随机化中候选工具变量多重效应自适应定位的联合似然统计方法研究, 2021/08/18-2025/12/31

4. 支撑精准智能诊疗的跨组学大数据因果推断理论方法及其智能系统研究, 2019/11/18-2024/12/31

5. 系统流行病学中多尺度高维因果中介分析的理论与统计方法研究, 2018/08/16-2022/12/31

6. 跨组学交互网络回归模型的构建及其统计推断方法研究, 2016/08/17-2020/12/31

7. 乳腺癌生物样本库及临床诊疗信息库建设-2, 2016/07/01-2020/12/31

8. 减盐预防高血压终期评估数据分析研究, 2015/11/20-2017/11/20

9. 盐敏感性高血压基因芯片的设计与制作研究, 2015/11/10-2017/11/10

10. 慢阻肺患者现场流行病学调查研究, 2015/10/01-2016/09/30

11. 青少年视力低下中医外治法防控技术临床评价及规范化研究, 2015/04/01-2017/12/31

12. 结直肠癌发生相关lncRNAs的筛选、验证及其血清学诊断价值研究, 2014/08/15-2018/12/31

13. 基于UPLC-MS的卵巢癌代谢组学生物标志物提取与预测模型研究, 2013/10/01-2016/10/31

14. 基于药物基因组学和临床特征的癫痫个性化治疗研究, 2013/08/15-2016/12/31

15. 自发性蛛网膜下腔出血预后风险评估预警系统及其规范化治疗决策支持系统研究, 2013/01/01-2015/12/31

16. 全基因组关联分析中基因-基因交互网络比较的统计推断方法研究, 2012/08/17-2015/12/31

17. 基于贝叶斯竞争风险理论的农村人群脑卒中发生和转归的适宜性风险预警策略与方法研究, 2012/08/17-2016/12/31

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