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韩琳
Professor
Visit:次
Personal Information
  • Name (Pinyin):
    hanlin
  • Date of Employment:
    2016-06-12
  • School/Department:
    海洋研究院
  • Education Level:
    Postgraduate (Doctoral)
  • Gender:
    Female
  • Degree:
    Doctor
  • Status:
    Employed
  • Alma Mater:
    美国普林斯顿大学
  • Supervisor of Master's Candidates
  • Supervisor of Doctorate Candidates
Discipline:
Microelectronics and Solid State Electronics;
Biomedical Engineering;
Honor:

2022    山东大学育人标兵；
2023    山东大学优秀教师（四有好老师）提名奖；
2022    第五届“中国创翼”创业创新大赛二等奖；
2021    中国济南新动能国际高层次人才创新创业大赛一等奖；
2021    首届山东大学十大高价值应用科技成果奖；
2022    山东大学杰出中青年学者；
2023    青岛市拔尖人才；
2018    山东省杰出青年基金获得者；
Biography

韩琳，山东大学海洋研究院/ 集成电路学院教授，博士生导师，山东大学杰出中青年学者，齐鲁青年学者，山东省杰出青年基金获得者。主要研究方向：面向生命健康和海洋环境监测的新型生物传感芯片与系统研发，开发了10余种国际先进水平的生物芯片（DNA、miRNA、抗原、抗体、外泌体、单细胞等）。近五年，以第一或通讯作者在 Chemical SocietyReview、Advanced Materials、Advanced Functional Materials、ACS Nano、Advanced Healthcare Materials等国际知名期刊发表学术论文60余篇，申请专利60余项，授权发明专利28项，实现了千万级的技术成果转化，相关成果被中央人民广播电台特别报道。主持国家重点研发计划（课题2项，子课题1项）、国家自然基金青年/面上、山东省杰出青年基金、山东省重大创新工程项目课题等10余项，担任山东大学青年交叉科学群体项目首席。曾获青岛市拔尖人才、山东大学杰出中青年学者、山东大学十大高价值应用科技成果奖、中国济南新动能国际高层次人才创新创业大赛一等奖等荣誉。担任卓越期刊BMEMat和Interdisciplinary Medicine编委，担任山东省医学会类器官分会第一届委员会、生物标志物与人工智能应用山东省工程研究中心副主任和济南市微纳传感芯片与智能装备重点实验室主任。

Education
  • 2006-09 — 2011-04
    普林斯顿大学
    电子工程与材料
    Doctoral Degree in Engineering
  • 2003-09 — 2006-07
    清华大学
    微电子
    Master's Degree in Engineering
  • 1999-09 — 2003-07
    山东大学
    微电子
    Bachelor's Degree in Science
Publication
Research Direction

1. 生物传感材料的电子传输机制、分子固载效率和转导增强机制研究，发展大面积均匀自组装的微条形阵列生物芯片基底

2. 生物传感器件与芯片的光、电传感机制研究，研发多种具有世界先进水平的核酸、蛋白、外泌体和单细胞检测微条形阵列传感芯片

3. 生物芯片检测系统在重大疾病标志物检测、疗效和预后评估、治疗细胞功能精准评估、食品与环境安全中的应用研究，形成自主可控的生物芯片产业化技术

Paper Publications

1. Sun, Mingyuan. Universal Amplification-Free RNA Detection by Integrating CRISPR-Cas10 with Aptameric Graphene Field-Effect Transistor .NANO-MICRO LETTERS.2025,17 (1)

2. Zhang, Yunhong. Multifunctional Flexible Sensor Based on Cracked Laser-Induced Graphene for Tactile Perception and Self-Healable Applications .ACS Applied Nano Materials.2024

3. Sun, Mingyuan. Laser-induced graphene van der Waals contact-enabled high-performance 2D-materials-based field-effect transistor .Carbon.2024,225

4. Zhou, Hongpeng. Self-assembled C-Ag hybrid nanoparticle on nanoporous GaN enabled ultra-high enhancement factor SERS sensor for sensitive thiram detection .JOURNAL OF HAZARDOUS MATERIALS.2024,469

5. Chen, Xiaoshuang. An rGO-doped laser induced graphene electrochemical biosensor for highly sensitive exosome detection .Sensors & Diagnostics.2024

6. Zhang, Yunhong. Microfluidic biosensing platform integrated with flexible sensing array for cancer biomarker point-of-care testing .SENSORS AND ACTUATORS B-CHEMICAL.2025,427

7. Li, Ping. Inhibitory effect of zinc oxide nanorod arrays on breast cancer cells profiled through real-time cytokines screening by a single-cell microfluidic platform . BMEMat.2023,1 (3)

8. Sun, Mingyuan. Flexible Graphene Field-Effect Transistors and Their Application in Flexible Biomedical Sensing .NANO-MICRO LETTERS.2025,17 (1)

9. Sun, Mingyuan. Recent Advances in Graphene Field-Effect Transistor Toward Biological Detection .Advanced Functional Materials.2024

10. Sun, Mingyuan. An ultrasensitive flexible biosensor enabled by high-performance graphene field-effect transistors with defect-free van der Waals contacts for breast cancer miRNA fast detection .TALANTA Journal.2025,287

11. Liang, Yanbo. Controllable nanopore SERS platform for single-molecule level biosensing .COORDINATION CHEMISTRY REVIEWS.2025,530

12. Qiu, Jiaoyan. Microfluidic Barcode Biochips for High-Throughput Real-Time Biomolecule and Single-Cell Screening .Engineering.2025

13. Wang, Shun. Ultrasensitive Antibiotic Perceiving Based on Aptamer-Functionalized Ultraclean Graphene Field-Effect Transistor Biosensor. .ANALYTICAL CHEMISTRY.2022,94 (42):14785-14793

14. Ji, Hao. Highly Stable InSe-FET Biosensor for Ultra-Sensitive Detection of Breast Cancer Biomarker CA125 .Biosensors-Basel.2023,13 (2)

15. Qiu, Jiaoyan. A self-assembly hydrophobic oCDs/Ag nanoparticles SERS sensor for ultrasensitive melamine detection in milk .Food Chemistry.2023,402

16. Huang, Di. A novel diagnostic signature of circulating tsRNAs and miRNAs in esophageal squamous cell carcinoma detected with a microfluidic platform .ANALYTICA CHIMICA ACTA.2023,1272

17. Huang, Yuzhen. Enhanced dual-mode electrochemical zinc ion sensing by electric field-driven bi-directional mass transport .Chemical Engineering Journal.2023,475

18. Huang, Yuzhen. Ceria and gold co-decorated porous MoS2@graphene nanocomposite electrochemical electrode integrated with smartphone-controlled microstation for simultaneous dual metal ions detection .ELECTROCHIMICA ACTA.2023,437

19. Wang, Min. A sensitive fluorescence assay based on aggregation-induced emission by copper-free click reaction for rapid ctDNA detection .Talanta.2023,259

20. He, Q.. Ag@C decorated GaN nanoflower enabled super-stable, single molecule level SERS substrate integrated with machine learning for multiple analytes identification .Materials Today Nano.2023,22

21. Wu, Yu. Multiple Biomarker Simultaneous Detection in Serum via a Nanomaterial-Functionalized Biosensor for Ovarian Tumor/Cancer Diagnosis .micromachine.2022,13 (12)

22. Jiang, Jianfeng. Construction of High Field-Effect Mobility Multilayer MoS2Field-Effect Transistors with Excellent Stability through Interface Engineering .ACS Applied Electronic Materials.2020,2 (7):2132-2140

23. Wu, Yu. A high-performance microfluidic detection platform to conduct a novel multiple-biomarker panel for ovarian cancer screening .RSC advances.2021,11 (14):8124-8133

24. Jiang, Jianfeng. Low Lattice Mismatch InSe-Se Vertical Van der Waals Heterostructure for High-performance Transistors via Strong Fermi-Level Depinning .Small Methods.2020,4 (8)

25. Chu, Yujin. Attomolar-Level Ultrasensitive and Multiplex microRNA Detection Enabled by a Nanomaterial Locally Assembled Microfluidic Biochip for Cancer Diagnosis .ANALYTICAL CHEMISTRY.2021,93 (12):5129-5136

26. Wang, Yanhao. Applications of 2D-Layered Palladium Diselenide and Its van der Waals Heterostructures in Electronics and Optoelectronics .NANO-MICRO LETTERS.2021,13 (1)

27. Gao, Jianwei. Graphene-based field-effect transistors integrated with microfluidic chip for real-time pH monitoring of seawater .Journal of Materials Science: Materials in Electronics.2020,31 (18):15372

28. Wu, Yu. A high-performance microfluidic detection platform to conduct a novel multiple-biomarker panel for ovarian cancer screening .RSC advances.2021,11 (14):8124

29. Sun, Baojun. Synthesis of Wafer-Scale Graphene with Chemical Vapor Deposition for Electronic Device Applications .Advanced Materials Technologies.2021

30. Wang, Yanhao. Performance-Enhanced CsPbBr3/HfO2/Si Heterostructure Optoelectronics through the Tunneling Effect .Advanced Materials Interfaces.2021

31. Chu, Yujin. Attomolar-Level Ultrasensitive and Multiplex microRNA Detection Enabled by a Nanomaterial Locally Assembled Microfluidic Biochip for Cancer Diagnosis .ANALYTICAL CHEMISTRY.2021,93 (12):5129

32. Wang, Yanhao. Applications of 2D-Layered Palladium Diselenide and Its van der Waals Heterostructures in Electronics and Optoelectronics .NANO-MICRO LETTERS.2021,13 (1)

33. Han, Yingkuan. Large-area surface-enhanced Raman spectroscopy substrate by hybrid porous GaN with Au/Ag for breast cancer miRNA detection .Applied Surface Science.2021,541

34. . A Sensitive and Portable Double-Layer Microfluidic Biochip for Harmful Algae Detection .micromachine.2022,13 (10)

35. Ji, Hao. A Novel InSe-FET Biosensor based on Carrier-Scattering Regulation Derived from the DNA Probe Assembly-Determined Electrostatic Potential Distribution .Advanced Functional Materials.2023,33 (14)

36. Cui, Tian-Rui. Ultrasensitive Detection of COVID-19 Causative Virus (SARS-CoV-2) Spike Protein Using Laser Induced Graphene Field-Effect Transistor .Molecules.2021,26 (22)

37. Chu, Yujin. Rapid and High-Throughput SARS-CoV-2 RNA Detection without RNA Extraction and Amplification by Using a Microfluidic Biochip .CHEMISTRY-A EUROPEAN JOURNAL .2022,28 (18)

38. Gao, Jianwei. Poly-L-Lysine-Modified Graphene Field-Effect Transistor Biosensors for Ultrasensitive Breast Cancer miRNAs and SARS-CoV-2 RNA Detection .ANALYTICAL CHEMISTRY.2022,94 (3):1626

39. He, Qihang. Reusable dual-enhancement SERS sensor based on graphene and hybrid nanostructures for ultrasensitive lead (II) detection .SENSORS AND ACTUATORS B-CHEMICAL.2021,341

40. Gao, Yakun. Rapid and sensitive triple-mode detection of causative SARS-CoV-2 virus speci fi c genes through interaction between genes and nanoparticles .ANALYTICA CHIMICA ACTA Journal.2021,1154

41. 王帅. Concurrent Detection of Amyloid-β Biomarkers via Dual-Channel Graphene Field-Effect Transistor with Liquid-Metal Van Der Waals Contacts for Alzheimer Screening .ACS SENSORS.2025 (7)

42. 李珺. Bipolar Ionic Diode with a Transformable Polyelectrolyte Network for High-Efficiency Ion Transport and Enhanced Sensitivity in Fluorescence-Based Heavy Metal Ion Detection .ANALYTICAL CHEMISTRY.2025 (28)

43. 王一鹤. In situ and dynamic screening of extracellular vesicles as predictive biomarkers in immune-checkpoint inhibitor therapies .Journal of Nanobiotechnology.2025 (1)

44. 陈镜. Performance Limits and Advancements in Single 2D Transition Metal Dichalcogenide Transistor .NANO-MICRO LETTERS.2024,16 (1)

45. 韩云蕊. Motion behaviors of droplets containing Au nanoparticles on a superhydrophobic laser-induced graphene surface .PHYSICS OF FLUIDS.2024,36 (7)

46. 韩云蕊. Suppression of coffee rings by controllable nanoparticle enrichment through superhydrophobicity-enabled dynamic evaporation .Journal of Colloid and interface science.2024,673 :735-745

47. . A Microfluidic 3D-Tumor-Spheroid Model for the Evaluation of Targeted Therapies from Angiogenesis-Related Cytokines at the Single Spheroid Level .Advanced Healthcare Materials.2024 (2402321)

48. . Lys-AuNPs@MoS2Nanocomposite Self-Assembled Microfluidic Immunoassay Biochip for Ultrasensitive Detection of Multiplex Biomarkers for Cardiovascular Diseases .ANALYTICAL CHEMISTRY.2022,94 (11):4720-4728

49. Yu Zhang * , Lin Han * ,  Yanbo Liang ,  Yunhong Zhang , Jiaoyan Qiu  and Hongpeng Zhou. Self-assembled C-Ag hybrid nanoparticle on nanoporous GaN enabled ultra-high enhancement factor SERS sensor for sensitive thiram detection .Journal of Hazardous Materials.2024 (1):133868

50. Tian-Ling Ren* ,  Xiao-Ming Wu* , Lin Han* ,  Yu Zhang ,  Shuai Wang ,  Ming-Yuan Sun ,  Zheng Zhang ,  Zheng-Hua Wang ,  Ye-Qing Zhu , Xue-Chun Zhao  and Jing Chen. Polarized Tunneling Transistor for Ultralow-Energy-Consumption Artificial Synapse toward Neuromorphic Computing .ACS Nano.2023,18 (1):581–591

51. Tian-Ling Ren* , * , * Xiaoming Wu , Lin Han ,  Yu Zhang ,  Shuai Wang ,  Ming-Yuan Sun ,  Zheng Zhang ,  Kai Zhang ,  Zheng-Hua Wang ,  Xue-Chun Zhao , Ye-Qing Zhu  and Jing Chen. PZT-Enabled MoS2 Floating Gate Transistors: Overcoming Boltzmann Tyranny and Achieving Ultralow Energy Consumption for High-Accuracy Neuromorphic Computing .Nano Letters.2023,23 (22):10196–10204

52. Lin Han* , Yu Zhang * ,  Jiaoyan Qiu ,  Xiaohui Yan ,  Xiaoshuang Chen , Kai Zhang  and Yuzhen Huang. Enhanced dual-mode electrochemical zinc ion sensing by electric field-driven bi-directional mass transport .Chemical Engineering Journal.2023,475 :146258

53. Lin Han* ,  Hong Liu* , Chunhua Wang*Yuanhua Sang* ,  Jichuan Qiu ,  Haina Huang ,  Ying Hou , Hongru Yang  and Chengming Lou. Microfluidic platforms for real-time in situ monitoring for biomarers for cellular processes .Advanced Materials.2023,36 (6):2307051

54. Lin Han* ,  Jianbo Wang ,  Han Shi ,  Yufeng Cheng ,  Shunjia Li ,  Yu Zhang ,  Junhua Zhao ,  Xiaoshuang Chen ,  Jiaoyan Qiu , Yujin Chu  and Di Huang. novel diagnostic signature of circulating tsRNAs and miRNAs in esophageal squamous cell carcinoma detected with a microfluidic platform .Analytica Chimica Acta.2023,1272 :341520

55. Lin Han* ,  Yu Zhang ,  Jonny J/ Blaker ,  Yuanhua Sang ,  Hao Ji ,  Kai Zhang ,  Yunhong Zhang ,  Yuzhen Huang ,  Fangteng Song ,  Jiaoyan Qiu , Chao Wang  and Ping Li. Inhibitory effect of zinc oxide nanorod arrays on breast cancer cells profiled through real-time cytokines screening by a single-cell microfluidic platform .BMEmat,.2023,1 (3):1-16

56. Lin Han* , Yu Zhang* ,  Hong Liu ,  Ben Zhong Tang ,  Xuewen He , Yujuan Zhao  and Min Wang. A sensitive fluorescence assay based on aggregation-induced emission by copper-free click reaction for rapid ctDNA detection .Talanta.2023,259 :124562

57. Lin Han* , Yu Zhang* ,  Hong Liu ,  Qihang He , Yingkuan Han  and Yunrui Han. Ultrasensitive and Reliable SERS Chip Based on Facile Assembly of AgNPs on Porous LIG to Enhance the Local Electromagnetic Field .the Journal of Physical Chemistry.2023,127 (8):4195–4202

58. Lin Han* , * , Yu Zhang ,  Yingkuan Han ,  Qihang He , Yujin Chu  and Jiaoyan Qiu. A self-assembly hydrophobic oCDs/Ag nanoparticles SERS sensor for ultrasensitive melamine detection in milk .Food Chemistry.2023,402 :134241

59. Lin Han* , Yu Zhang* ,  Kai Zhang ,  Chao Wang ,  Shun Wang , Zhenhua Wang  and Hao Ji. Highly stable Inse-FET biosensor for ultra-sensitive detection of breast cancer biomarker CA125 .Biosensors.2023,13 (2):193

60. Lin Han* ,  Hong Liu ,  Yu Zhang , Mengqi Liu  and Yihe Wang. Recent methods of droplet microfluidics and their applications in spheroids and organoids .Lab on a Chip.2023,23 (5):1080-1096

61. Lin Han* , Yu Zhang* ,  Min Wang ,  Yingkuan Han , Jiaoyan Qiu  and Qihang He. Ag@C decorated GaN nanoflower enabled super-stable, single molecule level SERS substrate integrated with machine learning for multiple analytes identification .Materials Today Nano.2023,22 :100305

62. Yuanhua Sang* , Lin Han* ,  Haijun Li ,  Jichuan Qiu ,  Dong Li ,  Liyang Yu ,  He Xia ,  Hang Zhao ,  Min Hao , Chao Wang  and Xin Chen. Mesoporous Silica Promotes Osteogenesis of Human Adipose-derived stem cells identified by a high-throughput microfluidic chip assay .Pharmaceutics.2022,14 (12):2730

63. Lin Han* , Yu Zhang* ,  Jiaoyan Qiu ,  Qihang He , Xiaohui Yan  and Yuzhen Huang. Ceria and gold co-decorated porous MoS2@graphene nanocomposite electrochemical electrode integrated with smartphone-controlled microstation for simultaneous dual metal ions detection .Electrochimica Acta.2022,437 :141509

64. Lin Han* , Yu Zhang* ,  Hong Liu ,  Jun Sun ,  Shuai Song ,  Jianwei Gao ,  Hao Ji ,  Yunhong Zhang , Mingyuan Sun  and Shun Wang. Ultrasensitive antibiotic perceiving based on aptamer-functionalized ultraclean graphene field-effect transistor biosensor .Analytical Chemistry.2022,94 (42):14785-14793

65. Lin Han* , Yu Zhang* ,  Yingkuan Han , Ping Li  and Yuzhen Huang. Controllable surface engineered three-dimensional porous graphene based electrode for ultrasensitive flexible electrochemical sensing .Applied Surface Science.2022,604 (12):154530

66. Lin Han* , * , * Yu Zhang , Hong Liu ,  Yihe Wang ,  Yu Wu ,  Jianbo Wang ,  Chunhua Wang , Chao Wang  and Fangteng Song. Multi-Phenotypic Exosome Secretion Profiling Microfluidic Platform for Exploring Single-Cell Heterogeneity .Small Methods.2022,6 (9):2200717

67. Lin Han ,  Shijie Mao , Zhongqian Liu  and Xiaowei Shao. Unravel the Mechanobiology Underlying Traumatic Brain Injury with Advanced Technologies and Biomaterials .Advanced Healthcare Materials.2022,11 (19):2200760

68. Lin Han* , Yu Zhang* ,  Jiayang Sun , Yingkuan Han  and Yuzhen Huang. Dual nanocatalysts co-decorated three-dimensional, laser-induced graphene hybrid nanomaterials integrated with a smartphone portable electrochemical system for point-of-care non-enzymatic glucose diagnosis .Materials Today Chemistry.2022,24 :100895

69. Lin Han* , Yongqiang Cheng* ,  Longyu Chen ,  Xiaoxiao Qi ,  Meijia Zhu ,  Ziwei Zhang , Xiaotong Li  and Ranran Xu. Aptamer-based signal amplification strategies coupled with microchips for high-sensitivity bioanalytical applications: a review .Analytica Chimica Acta.2022,1209 :339893

70. Lin Han* , Yu Zhang* ,  Xiaowei Shao ,  Yihe Wang ,  Fangteng Song ,  Yanhao Wang ,  Yakun Gao ,  Jiaoyan Qiu ,  Le Qiang ,  Yujin Chu ,  Yingkuan Han ,  Jianwei Gao ,  Yu Wu , Chunhua Wang  and Chao Wang. High-Throughput, Living Single-Cell, Multiple Secreted Biomarker Profiling Using Microfluidic Chip and Machine Learning for Tumor Cell Classification .Advanced Healthcare Materials.2022,11 (13):2102800

71. Lin Han* ,  Mei Zhang ,  Yu Zhang ,  Yujin Chu ,  Chunhua Wang , Peiqing Jiang  and Jiaoyan Qiu. Lys-AuNPs@MoS2 nanocomposites self-assembled microfluidic immunoassay biochip for the ultrasensitive detection of multiplex biomarkers for cardiovascular diseases .Analytical Chemistry.2022,94 (11):4720-4728

72. Yu Zhang* , Lin Han* ,  Hong Liu ,  Chao Wang ,  Yuzhen Huang , Yunrui Han  and Yingkuan Han. Laser-induced graphene superhydrophobic surface transition from pinning to rolling for multiple applications .Small Methods.2022,6 (4):2200096

73. Lin Han* ,  Yu Zhang ,  Min Wang ,  Yihe Wang ,  Jiaoyan Qiu , Yujin Chu  and Yujin Chu. Rapid and high-throughput SARS-CoV-2 RNA detection without RNA extraction and amplification using a microfluidic biochip .Chemistry-A European Journal.2022,28 (18):e202104054

74. Hong Liu* ,  Lin Han* ,  Ning Meng* , Chunhui Sun* ,  Jingang Wang ,  Jinbo Pang ,  Na Ren ,  Shuang Hu ,  Jian Wang ,  Na Liang ,  Haoyang Gao , Hongru Yang  and Zhijie Guo. Regulation of Neural Differentiation of ADMSCs using Graphene-Mediated Wireless-Localized Electrical Signals Driven by Electromagnetic Induction .Advanced Science.2022,9 (14):2104424

75. Lin Han* , Yu Zhang* ,  Hong Liu ,  Fangteng Song ,  Yingkuan Han ,  Yanhao Wang ,  Yankun Gao ,  Hao Ji ,  Mingyuan Sun ,  Shun Wang ,  Yujin Chu ,  Chao Wang , Chunhua Wang  and Jianwei Gao. Poly-L-Lysine-modified graphene field-effect transistor biosensor for ultrasensitive breast cancer miRNAs and SARS-CoV-2 RNA detection .Analytical Chemistry.2022,94 (3):1626–1636

76. Lin Han* , Yu Zhang* ,  Hong Liu ,  Jiayang Sun , Yingkuan Han  and Yunrui Han. Controllable nanoparticle aggregation through superhydrophobic laser-induced graphene dynamic system for surface-enhanced Raman scattering detection .ACS Applied Materials & Interfaces.2022,14 (2):3504-3514

77. Yu Zhang* , Lin Han* ,  Hong Liu ,  Chao Wang ,  Yanhao Wang ,  Yakun Gao ,  Yingkuan Han ,  Yujin Chu , Chunhua Wang  and Jianwei Gao. Graphene oxide-graphene Van der Waals heterostructure transistor biosensor for SARS-CoV-2 protein detection .Talanta.2021,240 :123197

78. Hong Liu* , Fan Yi* ,  Yuanhua Sang* , Lin Han* ,  Shuhua Wang ,  Chunhui Sun ,  Gang Li ,  Lin Han* ,  Feng Liu , Jiazhi Duan  and Ying Kong. Regulation of stem cell fate using nanostructure-mediated physical signals .Chemical Society Reviews.2021,50 (22):12828-12872

79. Lin Han* , Yu Zhang* ,  Dean Nizetic ,  Yunrui Han ,  Lei Han ,  Chao Wang , Chunhua Wang  and Xiaowei Shao. Mechanical stress induces a transient suppression of cytokine secretion in astrocytes assessed at the single-cell level with a high-throughput microfluidic chip .Advanced Healthcare Material.2021,10 (21):2100698

80. Yu Zhang* ,  Hong Liu* , Lin Han* ,  Yingkuan Han ,  Jianwei Gao ,  Hao Ji ,  Yujin Chu ,  Jinbo Pang ,  Qilin Cheng , Yunhong Zhang  and Yanhao Wang. Large area uniform PtSx synthesis on sapphire substrate for performance improved photodetectors .Applied Materials Today.2021,25 :101176

81. Yu Zhang* , Lin Han* ,  Yakun Gao ,  Jianwei Gao ,  Yuzhen Huang , Yingkuan Han  and Qihang He. Reusable dual-enhancement SERS sensor based on graphene and hybrid nanostructures for ultrasensitive lead (II) detection .Sensors and Actuators: B. Chemical.2021,341 :130031

82. Lin Han* , Yu Zhang* ,  Hong Liu ,  Jianwei Gao ,  Jiaoyan Qiu , Chao Wang  and Chunhua Wang. Ultrasensitive, high-throughput, and rapid simultaneous detection of SARS-CoV-2 antigens and IgG/IgM antibodies within 10 min through an immunoassay biochip .Microchimica Acta.2021,188 (8):262

83. Lin Han* , Yu Zhang* ,  Hong Liu ,  Jianwei Gao ,  Le Qiang ,  Yingkuan Han ,  Chao Wang , Wei Tang  and Chunhua Wang. Ultrasensitive, high-throughput and multiple cancer biomarkers simultaneous detection in serum based on graphene oxide quantum dots integrated microfluidic biosensing platform .Analytica Chimica Acta.2021,1178 :338791

84. Hong Liu* ,  Lin Han* , Jinbo Pang* ,  Haiyun Liu ,  Feng Yang ,  Hongbin Zhao ,  Bergoi Ibarlucea ,  Xue Meng ,  Yufen Li , Qilin Cheng  and Yanhao Wang. Gianaurelio Cuniberti, Applications of 2D Layered Palladium Diselenide and its van der Waals Heterostructures in Electronics and Optoelectronics .Nano-Micro Letters.2021,13 (1):143

85. Yu Zhang* , Lin Han ,  Hong Liu ,  Le Qiang ,  Jianwei Gao ,  Yingkuan Han ,  Yuhai Zhang ,  Depeng Shen ,  Hao Ji , Wei Zheng  and Yanhao Wang. Performance-Enhanced CsPbBr3/HfO2/Si Heterostructure Optoelectronics through the Tunneling Effect .Advanced Materials Interfaces.2021,8 (11):2100279

86. Hong Liu* ,  Shuhua Wang* , Lin Han* ,  Yuanhua Sang ,  Wenhu Yuan ,  Jiazhi Duan ,  Baojin Ma , Feng Liu  and Ying Kong. Wireless localized electrical stimulation generated by an ultrasound-driven piezoelectric discharge regulates proinflammatory macrophage polarization .Advanced Science.2021,8 (13):2100962

87. Lin Han* , Yu Zhang* ,  Hong Liu ,  Jianwei Gao ,  Chunhua Wang , Chao Wang  and Fagnteng Song. Enrichment-detection integrated exosome profiling biosensors promising for early diagnosis of cancer .Analytical Chemistry.2021,93 (11):4697–4706

88. Lin Han* ,  Hong Liu ,  Yu Zhang ,  Jianwei Gao ,  Yingkuan Han ,  Le Qiang ,  Wei Tang , Yakun Gao  and Yujin Chu. Attomolar-level ultrasensitive and multiplex miRNA detection enabled by a nanomaterials locally assembled microfluidic biochip for cancer diagnosis .Analytical Chemistry.2021,93 (12):5129–5136

89. Yu Zhang* , Lin Han* ,  Hong Liu ,  Yanhao Wang ,  Jianwei Gao ,  Le Qiang ,  Chao Wang , Yingkuan Han  and Yakun Gao. Rapid and sensitive triple-mode detection of causative SARS-CoV-2 virus specific genes through interaction between genes and nanoparticles .Analytica Chimica Acta.2021,1154 :338330

90. Lin Han* , Yu Zhang* ,  Guanqiu Xu ,  Jianbo Tu ,  Qihang He ,  Hao Ji ,  Jianwei Gao ,  Yakun Gao , Yingkuan Han  and Yuzhen Huang. Electrochemical sensor array with nanoporous gold nanolayer and ceria@gold corona-nanocomposites enhancer integrated into microfluidic for simultaneous ultrasensitive lead ion detection .Electrochimica Acta.2021,373 :137921

91. Yu* ,  Zhang ,  Lin* , Han ,  Liu Hong ,  He Qihang ,  Gao Jianwei ,  Gao Yakun , Qiang Le ,  Yingkuan  and Han. Large-area surface-enhanced Raman spectroscopy substrate by hybrid porous GaN with Au/Ag for breast cancer miRNA detection .Applied Surface Science.2020,541 (3):148456

92. Yu Zhang* ,  Lin Han* , Hong Liu* ,  Yakun Gao ,  Chao Wang ,  Yingkuan Han ,  Bin Wei , Jianwei Gao  and Yanhao Wang. Reduction of the ambient effect in multilayer InSe transistors and a strategy toward stable 2D-based optoelectronic applications .Nanoscale.2020,12 (35):18356-18362

93. Lin Han* , Hong Liu* ,  Xianjin Feng ,  Yuanhua Sang ,  Jinbo Pang ,  Hao Ji ,  Jiazhi Duan ,  Aizhu Wang , Yu Zhang  and Jianfeng Jiang. Construction of high field-effect mobility multilayer MoS2 Field-effect transistors with excellent stability through interface engineering .ACS Applied Electronic Materials.2020,2 (7):2132-2140

94. Lin Han* , Hong Liu* ,  Lin Gu ,  Xianjin Feng ,  Shanpeng Wang ,  Qinghua Zhang ,  Yu Zhang ,  Hao Ji ,  Weidong Xu ,  Jinbo Pang ,  Jie Qiao ,  Yuke Chen ,  Aizhu Wang ,  Qilin Cheng , Fanqi Meng  and Jianfeng Jiang. Low Lattice Mismatch InSe-Se Vertical Van der Waals Heterostructure for High-performance Transistors via Strong Fermi-level Depinning .Small Methods.2020,4 (8):2000238

95. Lin Han* ,  Jun Sun* , Yu Zhang* ,  Ian R/ Jenkinson ,  Yanyan Wang ,  Suchun Wang ,  Hong Liu ,  Qi Wu ,  Guangzhou Liu ,  Congcong Zhang ,  Yingkuan Han , Chao Wu  and Le Qiang. A Facile and Sensitive DNA Sensing of Harmful Algal Blooms Based on Graphene Oxide Nanosheets .Marine Biotechnology.2020,22 (4):498-510

96. Yuanhua Sang* ,  Hong Liu* , Lin Han* ,  Shuhua Wang ,  Jianjun Wang ,  Yu Zhang ,  Qilu Liu , Jianfeng Jiang  and Fulei Wang. Yuanhua Sang*, Piezopotential gated two-dimensional InSe field-effect transistor for designing a pressure sensor based on piezotronic effect .Nano Energy.2020,70 :104457

97. Lin Han* , Yu Zhang* ,  Hong Liu ,  Yanhao Wang ,  Wang Chao ,  Jinbo Pang ,  Yingkuan Han , Yakun Gao  and Jianwei Gao. Ultrasensitive Label-free MiRNA Sensing Based on a Flexible Graphene Field-Effect Transistor without Functionalization .ACS Applied Electronic Materials.2020,2 (4):1090-1098

98. Hong Liu* , Lin Han* ,  Yu Zhang ,  Feng Liu ,  Jiazhi Duan ,  Shan Zhang ,  Baojin Ma ,  Chao Wang ,  Chunhua Wang , Jianlong He  and Min Hao. Effect of hydroxyapatite nanorods on the fate of human adipose-derived stem cells assessed in Situ at the single cell level with a high-throughput, real-time microfluidic chip .Small.2019,15 (51):1905001

99. Lin Han* ,  Tian-ling Ren* , Yu Zhang* ,  Hong Liu ,  Qiqiang Li ,  Xianjin Feng ,  Haotian Zheng ,  Zhihua Zong ,  Ye Tian ,  Linshen Li ,  Jiazhi Duan ,  Yutao Li , Jingxin Li  and Jianfeng Jiang. Stable InSe Transistors with High-field Effect Mobility for Reliable Nerve Signal Sensing .Npj 2D Materials and Applications.2019,3 :29

100. Lin Han* ,  Hong Liu* , Lin Gu* ,  Yuanping Feng ,  Xianjin Feng ,  Congcong Zhang ,  Fanqi Meng ,  Yu Zhang ,  Aizhu Wang , Qinghua Zhang  and Jianfeng Jiang. A Facile and Effective Method for Patching Sulfur Vacancies of WS2 via Nitrogen Plasma Treatment .Small.2019,15 (36):1901791

101. Hong Liu* ,  Yuanhua Sang* ,  Jianjun Wang* , Lin Han* ,  Min Du ,  Ying Kong ,  Shicai Wang ,  Shan Zhang ,  Feng Liu , Baojin Ma  and Jiazhi Duan. Corrdination ability determined transition metal ions substitution of Tb in Tb-Asp fluorescent nanocrystals and a facile ions-detection approach .Nanoscale.2018,10 (16):7526

102. Xinghua Pan* ,  Rong Fan* , Franziska Michor* ,  Sherman M Weissman ,  Rafael Irizarry ,  In-Hyun Park ,  Michael Snyder ,  Jasper Han ,  Jennifer Yang ,  Xiaoyuan Zi ,  Ghia Euskirchen ,  Markus Riester ,  Sadie L Marjani ,  Kun-Yong Kim ,  Haiying Zhu , Huajun Wu  and Lin Han. Bisulfite-independent analysis of CpG island methylation enables genome-scale stratification of single-cells .Nucleic Acids Research.2017,45 (10):e77

103. Aimin Song* , Lin Han* ,  Qian Xin ,  Qingpu Wang ,  Gengchang Zhu , Yiming Wang  and Hanbin Wang. A novel thermally evaporated etching mask for low-damage dry etching .IEEE Transactions on Nanotechnology.2017,16 (2):290-295

104. Rong Fan* , Jonathan Chen ,  Lin Han#  and Minsuk Kwak#. Interfacing Nanowire arrays and living cells for cellular function analysis .Small.2015,11 (42):5600-5610

Patents

1. 一种基于高性能石墨烯晶体管的抗生素传感器及其制备方法和应用

2. 一种仿生超疏水-亲水集成孔板及基于该孔板的高通量自动化核酸建库仪

3. 多层结构柔性听觉神经刺激电极阵列

4. 一种外泌体微流控过滤系统，韩琳，褚玉金，张宇，ZL2020211235868，2021-05-14

5. 一种柔性类氧化硅薄膜大面积生长装置，张宇，韩琳，ZL2020212980656，2021-05-11

6. 一种用于抗体检测的双层微流控芯片，韩琳，王春华，张宇，刘宏，ZL2020211223396，2021-03-30

7. 一种用于肿瘤标志物检测的微流控芯片，韩琳，王春华，张宇，刘宏，ZL2020211223377，2021-03-30

8. 一种用于重金属离子检测的可重复使用SERS传感器，张宇，何启航，韩琳，韩应宽，ZL2020209754556，2021-03-30

9. 同一单细胞分泌蛋白、mRNA和DNA的同步检测芯片，韩琳，张宇，ZL2020212972359，2021-02-19

10. 无标记石墨烯场效应晶体管柔性生物传感器及可穿戴设备，韩琳，高建委，张宇，刘宏，ZL2020212295230，2021-02-19

11. 一种用于治疗细胞分泌蛋白检测的微流控芯片，韩琳，王超，张宇，ZL2020211342817，2021-02-19

12. 一种双层微流控芯片，韩琳，强乐，张宇，刘宏，王敏，ZL2020211236729，2021-02-19

13. 一种用于外泌体裂解和检测的微流控芯片，韩琳，褚玉金，张宇，ZL2020211229496，2021-02-12

14. 一种高亮度LED，张宇，韩琳，ZL2020210009268，2021-02-12

15. 一种重金属离子检测电化学微流控传感芯片，韩琳，黄煜真，张宇，ZL2020209822765，2021-02-12

16. 一种柔性类氧化硅薄膜生长装置，张宇，韩琳，ZL2020213090488，2021-01-26

17. 双色荧光双重检测的微流控芯片，韩琳，高亚坤，张宇，ZL202021123695X，2021-01-26

18. 微流控过滤芯片，韩琳，高亚坤，张宇，ZL2020211230421，2021-01-26

19. 一种静态细胞分析装置，韩琳，王超，张宇，ZL2020211216301，2021-01-26

20. 一种基于钙钛矿的新型异质结光电器件，张宇，王彦皓，韩琳，ZL2020210998871，2021-01-26

21. 一种探针分子印刷芯片，韩琳，张宇，ZL201822010638X，2020-01-03

22. 一种细胞分布分析装置，韩琳，张宇，ZL2018220106708，2020-01-03

23. 一种二硫化钼晶体管，韩琳，姜建峰，张宇，ZL2018215303053，2019-09-17

24. 一种硒化铟晶体管，韩琳，姜建峰，张宇，ZL2018215304412，2019-07-23

25. 一种二硫化钨晶体管，韩琳，姜建峰，张宇，ZL2018215304431，2019-07-23

26. 多层结构柔性听觉神经刺激电极阵列，田岚，韩琳，吴瑞安，马发江，霍新宇，ZL2017108121154，2024-01-30

27. 一种PtSx高性能光电器件及其制备方法和应用，张宇，韩琳，张云红，王彦皓，ZL2021110551975，2022-10-04

28. 一种自供电压力传感器及其制备方法，张云红，韩琳，张宇，王顺，ZL202210731008X，2023-05-09

29. 一种基于微流控芯片的单细胞分离装置及方法，李歧强，靳欣，韩琳，王兴元，ZL2019109520517，2022-08-26

30. 一种细胞分选与检测的微流控装置及方法，李歧强，靳欣，韩琳，ZL2019109520339，2022-08-02

31. CUL7在胶质瘤诊断、治疗和预后中的应用，薛皓，李刚，徐建业，邓林，郭钦栋，张宇，韩琳，刘宏，薛付忠，ZL201910532418X，2021-12-24

32. 一种类氧化硅柔性薄膜的生长方法，张宇，韩琳，ZL2020106399612，2021-09-24

33. 一种细胞分选与定位的微流控芯片及方法，靳欣，李歧强，韩琳，王兴元，ZL2019108619084，2021-07-13

34. 一种增加细胞产生的细胞外囊泡数量的挤压装置及其应用，李刚，张宇，薛皓，韩琳，郭钦栋，刘宏，ZL2019103951961，2020-08-11

35. 双层微流控芯片、包含该芯片的乳腺癌miRNA检测试剂盒及制备方法、检测方法，韩琳，褚玉金，张宇，ZL2020105534335，2024-01-02

36. 微流控过滤芯片、基于AuNPs的核酸三重检测试剂盒和方法，韩琳，高亚坤，张宇，ZL2020105534922，2024-01-02

37. 双色荧光双重检测的微流控芯片及方法，韩琳，高亚坤，张宇，ZL2020105539502，2023-12-15

38. 一种用于外泌体裂解和检测的微流控芯片及方法，韩琳，褚玉金，张宇，ZL2020105538764，2023-12-08

39. 一种无钉扎效应的激光诱导石墨烯的制备方法和应用，韩琳，张宇，韩应宽，韩云蕊，ZL2021116072245，2023-08-29

40. 一种便携式多路检测电化学传感系统及其应用，韩琳，黄煜真，张宇，ZL2022102748948，2023-08-11

41. 基于仿生的超疏水集成芯片的制备方法及SERS平台和应用，韩琳，韩云蕊，张宇，韩应宽，ZL202111607225X，2023-07-25

42. 一种基于微流控技术的抗体检测试剂盒及检测方法，韩琳，王春华，张宇，刘宏，ZL2020105530122，2023-07-21

43. 一种探针分子印刷芯片及其制造方法，韩琳，张宇，ZL201811458771X，2023-06-16

44. 一种生物分子检测方法，张宇，韩琳，ZL2018114587974，2022-06-24

45. 一种硒化铟晶体管及其制造方法，韩琳，姜建峰，张宇，ZL2018110871257，2022-04-15

46. 一种检测多种炎症因子的衬底及制备方法、试剂盒及应用，韩琳，邱教艳，张宇，王春华，ZL2022101657443，2023-03-28

47. 一种单细胞功能评估试剂盒及评估方法，韩琳，王超，张宇，ZL2020105526822，2022-12-02

48. 一种用于乳腺癌肿瘤标志物检测的试剂盒及方法，韩琳，王春华，张宇，刘宏，ZL2020105526911，2022-08-30

49. 一种基因检测芯片及检测方法，韩琳，褚玉金，张宇，ZL2020105526555，2022-08-30

Research Group
Name of Research Group:
 微纳生物传感芯片与系统
Description of Research Group:
 微纳生物传感芯片与系统是一支年轻的团队，2017年末开始建设，目前建成了具有6名中青年教师和20余名硕、博士研究生的具有微电子、材料、生物、临床医学、化学、机械、控制等多个学科的交叉型研究团队，建有从材料...
Members:
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